Drug-Induced Hypokalaemia

Salem, Chaker Ben; Hmouda, Houssem; Bouraoui, Kamel

doi:10.2174/157488609787354369

Cited by 31 publications

(19 citation statements)

References 96 publications

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“…Again, Gentamicin decreases serum potassium ion level, may be due its stimulatory effect on aldosterone secretion 22 . Furthermore, glomerular dysfunction and altered tubular reabsorption causes slightly increased level of sodium and decreased level of potassium and magnesium in gentamicin treated rats 18,23 .…”

Section: Discussionmentioning

confidence: 99%

Effects of Ashwagandha (Withania somnifera) Root Extract Against Gentamicin Induced Changes of Serum Electrolytes in Rats

Shimmi

Jahan

Sultana³

2012

J Bangladesh Soc Physiol

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Background: Regulation of electrolytes and body fluids are essential for maintaining the body homeostasis. Kidney plays an important role for these regulations. Higher doses of drugs, toxins, infectious agents, chemicals etc. can causes kidney damage and ultimately electrolytes disturbances can be occurred. Ashwagandha (Withania somnifera) is an herbal plant may have some role on serum electrolytes balance. Objective: To observe the effects of ashwagandha (Withania somnifera) root on serum electrolytes against gentamicin induced nephrotoxicity in Wistar albino rats. Methods: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from 1 st July 2010 to 30 th June 2011. A total number of 35 Wistar albino rats, age from 90 to 120 days, weighing between 150 to 200 grams were selected for the study. After acclimatization for 14 days, they were divided into control group and experimental group. Control group was again subdivided into baseline control, (10 rats) and gentamicin treated control group, (10 rats). Again, experimental group (gentamicin treated group after ashwagandha treatment) consisted of 15 rats. All groups of animals received basal diet for 22 consecutive days. In addition to this, gentamicin treated control group also received gentamicin subcutaneously (100mg /kg body weight/day) for the last eight (15 th to 22 nd day) consecutive days. Again, gentamicin treated group after ashwagandha treatment received ashwagandha root extract (500mg/kg body weight/day, orally) for 22 consecutive days and gentamicin subcutaneously (100mg/kg body weight /day) for last eight (15 th to 22 nd day) days. All the animals were sacrificed on 23 rd day. Then blood samples were collected and kidney weight was measured. For assessment of kidney function, some serum electrolyte levels e,g. serum sodium, potassium and chloride ion levels were estimated by ion selective electrode (ISE) electrolyte auto analyzer method, by using Biolyte 2000 auto analyzer . However, body weight and kidney weight of the animals were measured to assess the nephrotoxicity in these groups of animals. All these tests were done in the laboratory of Department of Physiology and Biochemistry, SSMC. Statistical analysis was done by one way ANOVA and Bonferroni tests as applicable. Results: The serum sodium and chloride ion levels were almost similar in all the groups and the differences were not statistically significant. The mean serum levels of potassium ion were significantly (p<0.001) lower in gentamicin treated group and (p<0.05) in gentamicin treated group after ashwagandha treatment in comparison to that of baseline control group. But this level of gentamicin treated group after ashwagandha treatment was significantly (p<0.01) higher than that of gentamicin treated group. Initial body weight was almost similar and no significant difference of this value was observed among the groups. Whereas, the final body weight was significantly (p<0.001) lower in gentamicin treated control gro...

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Section: Discussionmentioning

confidence: 99%

Effects of Ashwagandha (Withania somnifera) Root Extract Against Gentamicin Induced Changes of Serum Electrolytes in Rats

Shimmi

Jahan

Sultana³

2012

J Bangladesh Soc Physiol

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“…ACTH secretion leads to glucocorticoid excess and "spill over" effect on mineralocorticoid receptors in the distal nephron, resulting in enhanced potassium secretion [125]. Similar effects can be seen in patients on high dose steroid therapy and those receiving fludrocortisone, an oral mineralocorticoid, by its direct influence on mineralocorticoid receptors [122,126].…”

Section: Hypokalemiamentioning

confidence: 98%

Electrolyte Disorders in Cancer Patients

Latcha

2015

Onconephrology

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“…Drugs, including amphotericin, corticosteroids, diuretics, and salicylates, are also a common cause of either asymptomatic or symptomatic hypokalemia. 27 As mentioned above, hypochloremia due to vomiting and/or the abuse of diuretics and laxatives is among the most frequent electrolyte disturbances in patients suffering from AN. Other medical conditions associated with a decrease in serum chloride include excessive sweating, prolonged vomiting, salt-losing nephropathy, adrenocortical deficiency, acute intermittent porphyria, and SIADH.…”

Section: Electrolytesmentioning

confidence: 99%

Laboratory Parameters and Appetite Regulators in Patients with Anorexia Nervosa

Himmerich

Schönknecht²,

Heitmann³

et al. 2010

Journal of Psychiatric Practice

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Anorexia nervosa (AN) has serious negative effects on multiple organs and systems of the human body. As patients often do not make their eating disorder the subject of discussion, the physician is forced to rely on the physical examination and laboratory parameters as diagnostic hints. Obvious signs of AN are a body mass index (BMI) below 17.5 kg/m, dry and scaly skin, lanugo, edema, acrocyanosis, petechias, dental problems, and low blood pressure. However, because the often complex laboratory alterations can be difficult for the general psychiatrist to interpret, this article presents some useful guidelines. The plasma of patients with AN often shows alterations in laboratory parameters and appetite regulators, including electrolytes, liver enzymes, leukocyte count, hemoglobin (Hb), leptin, neuropeptide Y (NPY), triiodothyronine (T3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, ghrelin, pancreatic polypeptide (PP), tumor necrosis factor-alpha (TNF-alpha), and cortisol. Medical problems secondary to AN or due to the treatment itself may lead to further laboratory abnormalities. To date, despite these associated laboratory alterations, the diagnosis of anorexia is a clinical one, based on weight and specific psychopathology.

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Drug-Induced Hypokalaemia

Cited by 31 publications

References 96 publications

Effects of Ashwagandha (Withania somnifera) Root Extract Against Gentamicin Induced Changes of Serum Electrolytes in Rats

Effects of Ashwagandha (Withania somnifera) Root Extract Against Gentamicin Induced Changes of Serum Electrolytes in Rats

Electrolyte Disorders in Cancer Patients

Laboratory Parameters and Appetite Regulators in Patients with Anorexia Nervosa

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