Drug-Induced Illness Leading to Hospitalization

Abstract

\s=b\ During a three-year period, drug-induced illness, excluding suicide attempts and drug abuse, accounted for 2.9% of admissions to a medical service. There were proportionately fewer admissions for patients under 61 years of age than for those over. A considerably greater number of white women than black women or men were affected. More than 6% of these patients died.Eight drugs (aspirin, digoxin, warfarin sodium, hydrochlorothiazide, prednisone, vincristine sulfate, norethindrone, and furosemide) produced a third of the illnesses. In 18% of the cases an over-the-counter drug was implicated.Hemorrhagic effects occurred frequently. The cardiovascular, gastrointestinal, and hemopoietic systems were most often involved. Drug allergy was the mechanism of the adverse drug effect in 17.6% of the illnesses. The remainder were due to pharmacological mechanisms. (JAMA 228:713-717, 1974) CONCOMITANT

Development, implementation, and analysis of adverse drug reaction monitoring system in a rural tertiary care teaching hospital in Narketpally, Telangana

“…Antimicrobials were the most common drugs causing ADR indicating higher usage of these group of drugs. These findings are consistent with the previous studies by Patidar et al, 12 Murphy and Frigo, 14 and Caranasos et al 18 Causality assessment was done to further strengthen the validity of findings by using WHO-UMC scale. The majority of the ADRs belonged to the possible or probable category, but no reaction was categorized as definite.…”

Self‐medication in urban and rural Zimbabwean communities.

“…In the United States it is estimated that 18% of admissions to hospital for an adverse drug reaction are due to OTC drugs, with aspirin being the most commonly implicated drug (Caranasos et al, 1974). The minority of our respondents were aware that OTC drugs could be harmful and knowledge about aspirin, the most commonly used OTC drug, was unsatisfactory with only 18% of urban respondents and 15% of rural respondents aware that aspirin in overdose is potentially fatal.…”

Retrospective analysis of adverse drug reactions reported at ADR monitoring centre under PvPI in a tertiary care hospital

“…This pattern has been reported in other study also. 16 Parenteral route (IV) was most commonly involved in ADR (57%) followed by oral route (41%). Topical route is least involved in ADR (2%).…”