Drug‐Induced Liver Disease

Acute Aripiprazole-Associated Liver Injury

“…Roussel Uclaf causality assessment method (RUCAM) was used to assess the likelihood of DILI. Roussel Uclaf causality assessment method assesses for drug injury by considering the temporal relationship, course after cessation of the drug, risk factors, concomitant drug usage, nondrug causes, previous information on drug, and response to rechallenge 9 . Ms B's RUCAM score of 8 was suggestive of probable drug-related liver injury (>8, highly probable; 6–8, probable; 3–5, possible; 1–2, unlikely; 0, excluded).…”

“…Mutations or polymorphisms in glutathione S-transferase, manganese superoxide dismutase, human leukocyte antigen genotypes, and enzymes in drug metabolism can predispose to idiosyncratic drug-associated liver injury. Although underlying liver disease may predispose to medication toxicity, it is important to distinguish that it does not increase sensitivity for hepatic injury 9 …”