Drug-induced liver injury after covid-19 mRNA vaccine: case report

Abstract

Case description:A 22-year-old female patient received the first dose of Pfizer-BioNTech vaccine (RNAm) against COVID-19; 6 days later, she presented abdominal pain located in the right hypochondrium and epigastrium, associated with emetic episodes. Consultation 21 days later due to the same symptoms; three days after the seconddose of the vaccine was administered. 
 Clinical findings:Pain on palpation in the right hypochondrium. Laboratories reported hepatocellular lesions and cholestasis, with negative amylase, hepatotropic virus and autoimmune hepatitis tests. Liver and biliary tract ultrasound and cholangioresonance were normal.
 Treatment and Results:Hyoscine and intravenous fluids as support therapy. She presented improvement in abdominal pain and a progressive decrease of transaminases and bilirubin levels until normalization and was discharged on the fifth day of hospitalization. A drug-associated hepatotoxicity (DILI) diagnosis was considered probable, in this case, secondary to vaccination against COVID-19. 
 Clinical Relevance:The current SARS-CoV-2 pandemic has spurred the development of new vaccines, the safety of which remains a concern. There is a likely causal relationship between vaccination and liver involvement in this clinical case rather than simply a sporadic occurrence.

Retrospective study about clinical severity and epidemiological analysis of the SARS-CoV-2 Omicron subvariant lineage-infected patients in Hohhot, China

“…Since the SARS-CoV-2 outbreak, people have started to pay attention to the superimposed impact of the virus and other diseases, among them the chronic liver disease (CLD) is the most typical disease [27,28] . Meanwhile, people have been worried that the dual impact of COVID-19 and CLD would not be harmful to SARS-CoV-2 [29,30] .…”

Perspective Chapter: SARS-CoV-2 Vaccine-Related Liver Failure – Active Hepatitis B and Comprehensive Literature Analysis

“…[9][10][11][12][13][14]. Liver injury caused by SARS-CoV-2 mRNA vaccines (Pfizer-BioNTech, Oxford-AstraZeneca, and Moderna) has also been reported in many countries [6,8,15]. A small number of vaccinated cases have developed liver damage or liver failure (LF) and even require liver transplantation, but so far, vaccination-generated liver damage has responded well to therapy [8,16].…”