Drug-induced liver injury: present and future

Suk, Ki Tae; Kim, Dong Joon

doi:10.3350/cmh.2012.18.3.249

“…4 Common drugs causing hepatitis are drugs like methotrexate, amiodarone, statins, halothane, isoniazid, rifampicin, and pyrazinamide. [5][6][7] Common histopathology of drug-induced hepatitis is similar to that of acute viral hepatitis, however some drugs like erythromycin show a cholestatic picture.…”

Section: Discussionmentioning

confidence: 99%

A rare case of neomercazole induced hepatitis

Varma

¹

,

Mansingh

²

,

Sivakumar

³

et al. 2018

Int J Res Med Sci

0

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Neomercazole is one of the most commonly used drugs to treat hyperthyroidism. Common side effects include rash, hair loss and agranulocytosis. Hepatotoxicity is a common side effect of Propylthiouracil, the other major antithyroid drug, but it has been rarely described as a side effect of neomercazole. Here, a patient presents with hepatitis 6 months after starting neomercazole therapy for graves disease. Diagnosis is based on excluding other causes of hepatitis, and treatment involves removing the offending drug. This is followed by normalization of liver function. Rechallenging should not be done as it can lead to recurrence of symptoms.

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“…DILI has been reported to be widely caused by a variety of pharmaceuticals, herbs, and other toxic substances. In Western countries, 1.2%-6.6% of acute liver disease cases reported at tertiary referral centers were related to DILI, and it also accounts for 13% of acute liver failure [42,43]. According to the -value between ALT (serum alanine aminotransferase) and ALP (alkaline phosphatase), clinical DILI cases were classified into hepatocellular, cholestatic, and mixed types [44].…”

Section: Clinical Features Of Dili/hilimentioning

confidence: 99%

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Kim¹,

Kim²,

Go³

et al. 2017

J Int Korean Med

0

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In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact, is overestimated. Up to date, the investigation of hepatotoxicity of CHM is now booming with worldwide application of CHM. This review therefore provides useful information for investigating hepatotoxicity of herbal medicine and characterizing DILI caused by CHM. In addition, authors describe in which way further efforts should be made to study the rationale of CHM and liver injury.

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“…In Western countries, 1.2%–6.6% of acute liver disease cases reported at tertiary referral centers were related to DILI, and it also accounts for 13% of acute liver failure [42, 43]. According to the R -value between ALT (serum alanine aminotransferase) and ALP (alkaline phosphatase), clinical DILI cases were classified into hepatocellular, cholestatic, and mixed types [44].…”

Section: Diagnosis and Treatment Of Hili In Chinamentioning

confidence: 99%

Research Advances on Hepatotoxicity of Herbal Medicines in China

Liu

¹

,

Fan

²

,

Li

³

et al. 2016

BioMed Research International

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In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact, is overestimated. Up to date, the investigation of hepatotoxicity of CHM is now booming with worldwide application of CHM. This review therefore provides useful information for investigating hepatotoxicity of herbal medicine and characterizing DILI caused by CHM. In addition, authors describe in which way further efforts should be made to study the rationale of CHM and liver injury.

show abstract

Drug-induced liver injury: present and future

Cited by 135 publications

References 51 publications

A rare case of neomercazole induced hepatitis

A rare case of neomercazole induced hepatitis

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Research Advances on Hepatotoxicity of Herbal Medicines in China

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