Drug-induced myopathies

Zuckner, Jack

doi:10.1016/0049-0172(90)90048-k

Cited by 17 publications

(4 citation statements)

References 65 publications

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“…Myopathy has rarely been reported with these agents [30] . Clinicians should be aware that treatment may lead to neuromyopathy as well as irreversible retinopathy with chronic use.…”

Section: Myopathymentioning

confidence: 99%

Antimalarial Drug Toxicity: A Review

2007

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Antimalarial drug toxicity is viewed differently depending upon whether the clinical indication is for malaria treatment or prophylaxis. In the treatment of Plasmodium falciparum malaria, which has a high mortality if untreated, a greater risk of adverse reactions to antimalarial drugs is inevitable. As chloroquine resistance has become widespread, alternative agents may be used in treatment regimens, however, the toxicity of these antimalarial agents should be considered. Quinine is the mainstay for treating severe malaria due to its rare cardiovascular or CNS toxicity, but its hypoglycemic effect may be problematic. Mefloquine can cause dose-related serious neuropsychiatric toxicity and pyrimethamine-dapsone is associated with agranulocytosis, especially if the recommended dose is exceeded. Pyrimethamine-sulfadoxine and amodiaquine are associated with a relatively high incidence of potentially fatal reactions, and are no longer recommended for prophylaxis. Atovaquone/proguanil is an antimalarial combination with good efficacy and tolerability as prophylaxis and for treatment. The artemisinin derivatives have remarkable efficacy and an excellent safety record. Prescribing in pregnancy is a particular problem for clinicians because the risk-benefit ratio is often very unclear.

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“…Myopathy has rarely been reported with these agents [30] . Clinicians should be aware that treatment may lead to neuromyopathy as well as irreversible retinopathy with chronic use.…”

Section: Myopathymentioning

confidence: 99%

Antimalarial Drug Toxicity: A Review

2007

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“…Myopathy that is secondary to exposure to drugs or toxins, many of which are common, needs to be considered but in this case can be ruled out on the basis of the history. 4 In this patient, the signs, symptoms, and laboratory abnormalities suggest an inflammatory myopathy, examples of which include dermatomyositis, polymyositis, and inclusion-body myositis. [5][6][7][8][9] The myopathy that is typically seen in patients with scleroderma and the undifferentiated connectivetissue diseases seemed unlikely possibilities, because the patient had none of the specific stigmata associated with these diseases.…”

mentioning

confidence: 88%

Case 29-2005

Polisson¹,

Crocker²,

Müeller³

et al. 2005

N Engl J Med

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“…For the vast majority of patients, statins are a safe and effective way of lowering the cholesterol level, but for a relatively small number of patients, myalgia is a recognized feature. Other drugs, including D‐penicillamine, have also been described to induce a polymyositis such as inflammatory myopathy (7). This link between statins and a necrotizing myopathy has been noted previously (8) and prompts consideration of the immunopathogenesis of myositis in general and in this newly recognized subset of patients in particular.…”

Section: Syndromes Associated With Myositis‐specific Autoantibodiesmentioning

confidence: 99%

“Muscles … and bones”

Isenberg

2010

Arthritis & Rheumatism

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A uniaxial tensile test was performed for polycarbonate (PC)/high‐density polyethylene (HDPE)/ethylene–vinyl acetate copolymer (EVA) blends with a fixed EVA content but various PC contents. The double‐yielding phenomenon and its composition dependence, as observed in the PC/HDPE blend, were again detected. EVA did not serve as a successful compatibilizer of PC and HDPE in the PC/HDPE/EVA blend. The incorporation of EVA resulted in a larger size and a more irregular shape of the PC fibers, as indicated in the scanning electron microscope observations; this, consequently, produced a higher serious stress concentration in the blend. This more complicated and instable morphology produced different double‐yielding behaviors in the PC/HDPE/EVA blends compared with the binary one. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008

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Drug-induced myopathies

Cited by 17 publications

References 65 publications

Antimalarial Drug Toxicity: A Review

Antimalarial Drug Toxicity: A Review

Case 29-2005

“Muscles … and bones”

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