Drug-Induced Nephrotoxicity and Its Biomarkers

Kim, Sun Young; Moon, Aree

doi:10.4062/biomolther.2012.20.3.268

Cited by 229 publications

(161 citation statements)

References 56 publications

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“…However, the underlying molecular mechanisms of cisplatin-induced apoptosis of kidney cells are not yet fully understood. The lack of early biomarkers is another issue that makes it difficult to initiate potential therapeutic or preventive interventions for cisplatin-induced nephrotoxicity in a timely manner (3,4).…”

mentioning

confidence: 99%

Role of Annexin A5 in Cisplatin-induced Toxicity in Renal Cells

Jeong

Park

Kwon

et al. 2014

Journal of Biological Chemistry

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Background: There is increasing evidence that annexin A5 is related to cytotoxicity, but the precise function has yet to be elucidated. Results: Cisplatin induces mitochondrial translocation of annexin A5, and annexin A5 mediates VDAC oligomerization. Conclusion: Annexin A5 may play a role as a mediator of cisplatin-induced apoptosis in renal epithelial cells. Significance: Learning how annexin A5 is involved in the apoptotic pathway is crucial for understanding cisplatin-induced toxicity.

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mentioning

confidence: 99%

Role of Annexin A5 in Cisplatin-induced Toxicity in Renal Cells

Jeong

Park

Kwon

et al. 2014

Journal of Biological Chemistry

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“…However, these results suggest that an HFD cannot directly decrease renal function in rats. Although we did not check urinary markers for renal function, it is well known that renal histological alterations are highly correlated with renal function (51,52). In the present study, we demonstrated the HFD plus the long-term injection of d-galactose in the rat kidney induces more severe oxidative stress and leads to apoptotic renal cell death.…”

Section: Discussionmentioning

confidence: 42%

A High-Fat Diet Increases Oxidative Renal Injury and Protein Glycation in D-Galactose-Induced Aging Rats and Its Prevention by Korea Red Ginseng

Park

Kim

Min

et al. 2014

J Nutr Sci Vitaminol

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Summary Declining renal function is commonly observed with age. Obesity induced by a high-fat diet (HFD) may reduce renal function. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury and have an anti-aging effect. This study was designed to investigate whether HFD would accelerate the d-galactose-induced aging process in the rat kidney and to examine the preventive effect of KRG on HFD and d-galactose-induced aging-related renal injury. When rats with d-galactose-induced aging were fed an HFD for 9 wk, enhanced oxidative DNA damage, renal cell apoptosis, protein glycation, and extracellular high mobility group box 1 protein (HMGB1), a signal of tissue damage, were observed in renal glomerular cells and tubular epithelial cells. However, treatment of rats with HFDplus d-galactose-induced aging with KRG restored all of these renal changes. Our data suggested that a long-term HFD may enhance d-galactose-induced oxidative renal injury in rats and that this age-related renal injury could be suppressed by KRG through the repression of oxidative injury.

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“…1 Drugs such as antibiotics became the major implicating factor in the acute kidney injury due to indigenous functions of kidney to excrete them. This acute renal injury often leads to renal failure which in turn is associated with other pathological manifestations such as sepsis, cardiovascular disorders and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…However, higher concentrations of these antibiotics are nephrotoxic. 1 Gentamicin induced renal damage is widely used model for inducing nephrotoxicity in experimental animals. 4 It is characterized by direct tubular necrosis, which is localised mainly in the proximal tubules.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Effect of Anethum Graveolens in a Murine Model of Gentamicin Induced Nephrotoxicity

Srivastava¹,

Rashmi

Shenoy

et al. 2018

JYP

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Background: Antioxidant rich herbs possess significant activity against various disease conditions induced by oxidative stress. Anethum graveolens is a rich source of bioactive compounds that possess varying pharmacological activities including antioxidant. Objective: To evaluate the nephroprotective effect of aqueous extract of Anethum graveolens seeds in a murine model of gentamicin induced renal damage. Materials and Methods: Wistar albino rats of either sex, weighing 150-200g were divided into 5 groups; normal saline, gentamicin (80 mg/kg, i.p), aqueous extract of Anethum graveolens seeds at 0.5, 1 and 2g/kg/ body wt., p.o, for 8 days, the extract being administered 3 days prior and concurrently with gentamicin for 5 days. Serum urea, creatinine, uric acid, blood urea nitrogen (BUN) analyses and histopathological examination of kidney were performed. Results: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in Serum urea, creatinine, uric acid and BUN (107.5±16.92 mg/dl, 0.88±0.09 mg/dl,3.05±0.29 mg/dl and 47.80±9.07 mg/dl respectively) as compared to saline treated animals. Co-administration of aqueous extract of Anethum graveolens at doses 0.5, 1 and 2g/kg/ body wt decreased the rise in these parameters in a dose dependent manner. However statistical significance was obtained only with 1 and 2g/kg body wt doses employed, when compared to the gentamicin treated group. Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas the test extract mitigated the severity of gentamicin induced renal damage. Conclusion: Our data suggests that aqueous extract of Anethum graveolens seeds exhibits renoprotective effect in gentamicin induced renal damage probably due to its antioxidant actions. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Drug-Induced Nephrotoxicity and Its Biomarkers

Cited by 229 publications

References 56 publications

Role of Annexin A5 in Cisplatin-induced Toxicity in Renal Cells

Role of Annexin A5 in Cisplatin-induced Toxicity in Renal Cells

A High-Fat Diet Increases Oxidative Renal Injury and Protein Glycation in D-Galactose-Induced Aging Rats and Its Prevention by Korea Red Ginseng

Nephroprotective Effect of Anethum Graveolens in a Murine Model of Gentamicin Induced Nephrotoxicity

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