Drug-induced nephrotoxicity

Dhodi, Dinesh K; Bhagat, Sagar; Pathak, Deepanjali; Patel, Sadiq B

doi:10.5455/2319-2003.ijbcp20140826

Cited by 23 publications

(28 citation statements)

References 26 publications

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“…Multiple daily dosage is also known to likely predispose patients to nephrotoxicity than once daily dosage (13,15). With most of the patients on multiple daily dosage (73%) therapy rather than the once daily dose, the patients were at a greater risk of nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Gentamicin Therapeutic Drug Monitoring: Importance in the Hospital Setting

Mason¹,

Verley²,

Gossell‐Williams³

et al. 2016

West Indian Med J

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Background: The use of gentamicin places patients at risk of developing drug-induced nephrotoxicity, requiring special consideration to be given to serum creatinine monitoring and therapeutic drug monitoring (TDM). Objectives: To evaluate the prevalence of nephrotoxicity without the availability of TDM. Methods: A prospective study was used to recruit patients, 18 years and older who were to receive intravenous gentamicin administration between July 2013 and July 2014 at the University Hospital of the West Indies. Their data collected included: demographics, type of infection, gentamicin dose regimen, concomitant drugs and serum creatinine. Nephrotoxicity was defined as 1.5 times or more increase in serum creatinine concentration above the baseline. Results: Eleven patients were included in the study; six (55%) were males, their median age was 51 years (range: 33-84 years). All the patients had normal baseline serum creatinine, median 56 (range: 22-94) µmol/L and had regular monitoring of serum creatinine during therapy. The median gentamicin dose was 160 mg/day (range: 50-240 mg/day) and median treatment length was eight days (range: 5-30 days). Evidence of nephrotoxicity was observed in six (55%) patients by day seven of therapy. All the patients had at least one risk factor predisposing them to nephrotoxicity including prolonged therapy (10/11), multiple daily dosing regimen (8/11), receiving concomitant nephrotoxic drugs (9/11) and age (6/11). Conclusion: Although vigilant monitoring of serum creatinine is useful for safety monitoring, with most patients experiencing some levels of nephrotoxicity and having at least one predisposing risk factor, consideration should be given to the implementation of TDM.

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Section: Discussionmentioning

confidence: 99%

Gentamicin Therapeutic Drug Monitoring: Importance in the Hospital Setting

Mason¹,

Verley²,

Gossell‐Williams³

et al. 2016

West Indian Med J

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“…During the therapy with NSAIDs continuously monitor patient renal function. Habitual use of NSAIDs should be avoided and also avoid combination with other analgesics (Dhodi et al, 2014;Singh et al, 2003).…”

Section: Mechanismmentioning

confidence: 99%

“…Detoxi ication by antioxidant drugs plays an important role in cisplatin-induced renoprotection (Dhodi et al, 2014;Hajian et al, 2014).…”

Section: Preventionmentioning

confidence: 99%

“…Nowadays, drug-induced renal disease is increased due to the rise in the usage of drugs and their availability in the market at easy (Jha and Chugh, 1995;Singh et al, 2003). Drug-induced nephrotoxicity is summed up as renal dysfunction or disease, which turns up as a consequence of indirect or direct exposure of the drug (Dhodi et al, 2014). The prevalence of drug-induced nephrotoxicity is 14-6% and 16% in adults and pediatrics, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…The risk factors, which cause renal dysfunctions, are categorized into three, such as, Patient-related, kidney-related, and drug-related factors. (Dhodi et al, 2014;Naughton, 2008) The major risk factors which causing nephrotoxicity are mentioned in Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Drug-induced renal disorder-A Mini Review

Divya¹,

Nivetha²,

Mohan³

et al. 2020

ijrps

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Drug-induced kidney disorder/disease (DKID) is an origin of kidney disease followed by acute renal failure. Drug-induced renal toxicity is more common in infants and young children in certain clinical circumstances where underlying renal dysfunction and cardiovascular diseases. Sometimes, administered drugs may cause acute renal injury, intra-renal obstruction, interstitial nephritis, nephrotic syndrome, and acid-base and fluid electrolytes disorders in patients. Certain drugs may cause alterations in intra-glomerular hemodynamics, inflammatory changes in renal tubular cells, leading to acute kidney injury (AKI), interstitial tubule disease, and renal scarring. Common risk factors include; pre-existing renal dysfunction, volume-depleted state, old age, and use of nephrotoxic drugs. Therefore, the prevention from the disease includes the knowledge about the nephrotoxicity, assessing considering the patient-related, kidney-related, and drug-related factors while prescribing medicines, using of alternative drugs, which are non-nephrotoxic, assessing the baseline of renal function before starting the treatment, monitor the renal function during the treatment and avoid the nephrotoxic drug combinations and withdrawing the offending drugs due to toxicity. The ADRs of the prescribed/ administered are identified at the earliest to prevent the development of the last-stage renal disorder. This review discusses the risk factors associated with drug-induced renal disease, estimation of renal function, mechanism of drug-induced nephrotoxicity, and certain drugs that cause nephrotoxicity.

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Evaluation of the nephroprotective effect of Glycyrrhiza glabra L aqueous extract on CCl4-induced nephrotoxicity in mice

Zangeneh

Tahvilian

et al. 2018

Comp Clin Pathol

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Drug-induced nephrotoxicity

Cited by 23 publications

References 26 publications

Gentamicin Therapeutic Drug Monitoring: Importance in the Hospital Setting

Gentamicin Therapeutic Drug Monitoring: Importance in the Hospital Setting

Drug-induced renal disorder-A Mini Review

Evaluation of the nephroprotective effect of Glycyrrhiza glabra L aqueous extract on CCl4-induced nephrotoxicity in mice

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