Drug-Induced Neutropenia During Treatment of Non-Neoplastic Dermatologic Diseases: A Review

Hsieh, Chang-Yu; Tsai, Tsen‐Fang

doi:10.1007/s40261-020-00956-w

Clin Drug Investig

2020

DOI: 10.1007/s40261-020-00956-w

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Drug-Induced Neutropenia During Treatment of Non-Neoplastic Dermatologic Diseases: A Review

Chang-Yu Hsieh

Tsen‐Fang Tsai

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Cited by 3 publications

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Idiosyncratic Reaction of Isotretinoin: A Review

Lee,

Chan,

Lee

et al. 2024

Dermatological Reviews

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BackgroundIsotretinoin is widely recognized for its efficacy in treating severe acne. However, its use is associated with a variety of idiosyncratic reactions that can affect multiple organ systems and bodily functions, necessitating vigilant monitoring and appropriate management.ObjectivesThe aim of this review is to raise awareness of the broad spectrum of adverse effects linked to isotretinoin therapy, thereby enhancing the ability of healthcare providers to identify at‐risk individuals and improve patient outcomes.MethodsA comprehensive review of current literature was conducted to explore the range of idiosyncratic reactions associated with isotretinoin. The focus was on identifying the types of adverse effects reported and the necessary monitoring strategies to mitigate these risks.ResultsIsotretinoin has been linked to a wide array of adverse effects, including, but not limited to, psychiatric issues (e.g., depression and suicidal behavior), hematological complications (e.g., neutropenia and agranulocytosis), gastrointestinal disturbances, cardiovascular effects, dermatological manifestations, hepatobiliary issues, ophthalmological changes, and orthopedic concerns. These reactions highlight the importance of careful patient monitoring during isotretinoin therapy.ConclusionHealthcare professionals prescribing isotretinoin must be aware of the potential for diverse idiosyncratic reactions and should implement appropriate monitoring protocols to ensure patient safety. By understanding and anticipating these adverse effects, healthcare providers can better manage the risks associated with isotretinoin use, ultimately improving the quality of care for patients undergoing treatment for severe acne.

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Idiosyncratic Reaction of Isotretinoin: A Review

Lee,

Chan,

Lee

et al. 2024

Dermatological Reviews

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Immunosuppressants against acute kidney injury: what to prefer or to avoid?

Mishra,

Shelke,

Dagar

et al. 2024

Immunopharmacology and Immunotoxicology

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Chronic neutropenia: how best to assess severity and approach management?

Donadieu

Frenz

Merz

et al. 2021

Expert Review of Hematology

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Introduction: Neutropenia is a relatively common finding in medical practice and the medical approach requires a gradual and pertinent diagnostic procedure as well as adapted management. Areas Coverered:The area of chronic neutropenia remains fragmented between diverse diseases or or situations. Here physicians involved on different aspects of chronic neutropenia gather both the data from medical literature till the end of may 2021 and their experience to offer a global approach for the diagnosis of chronic neutropenia as well as their medical care.Expert opinion. In most cases, the neutropenia is transient, frequently related to a viral infection, and not harmful. However, neutropenia can be chronic (i.e., >3 months) and related to a number of etiologies, some clinically benign, such as so-called "ethnic" neutropenia,. Autoimmune neutropenia is the common form in young children, whereas idiopathic/immune neutropenia is a frequent etiology in young females. Inherited neutropenia (or congenital neutropenia) is exceptional, with approximately 30 new cases per 10 6 births and 30 known subtypes. Such patients have a high risk of invasive bacterial infections, and oral infections. Supportive therapy, which is primarily based on daily administration of an antibiotic prophylaxis and/or treatment with granulocyte-colony stimulating factor (G-CSF), contributes to avoiding recurrent infections.

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Drug-Induced Neutropenia During Treatment of Non-Neoplastic Dermatologic Diseases: A Review

Cited by 3 publications

References 93 publications

Idiosyncratic Reaction of Isotretinoin: A Review

Idiosyncratic Reaction of Isotretinoin: A Review

Immunosuppressants against acute kidney injury: what to prefer or to avoid?

Chronic neutropenia: how best to assess severity and approach management?

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