Drug induced nightmares—an etiology based review

Pagel, J.F.; Helfter, P.

doi:10.1002/hup.465

Cited by 134 publications

(64 citation statements)

References 37 publications

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“…1,15 Changes in dream content with more vivid and intense dreams and nightmares have been reported among subjects taking serotonergic antidepressants. [16][17][18] In our study, there was a parallel diminution of clinical RBD symptoms and severity of nightmares and dream enactments upon amendment of the antidepressant regimen. Thus, a distinct possibility remained that a serotonergic antidepressant could partially exert its effect by the modulation of dream mechanism.…”

supporting

confidence: 63%

REM Sleep Behavior Disorder in Psychiatric Populations

Lam¹,

Zhang²,

Tsoh³

et al. 2010

J. Clin. Psychiatry

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To the Editor: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a loss of REMrelated muscle atonia and abnormal motor activities during REM sleep with consequent sleep-related injuries. 1,2 It has been increasingly reported among psychiatric populations and has a potential association with use of psychotropics, particularly selective serotonin reuptake inhibitor (SSRI), tricyclic, and serotonin and noradrenergic reuptake inhibitor (SNRI) antidepressants. [3][4][5][6][7][8] A previous case report 5 found that cessation of SSRI treatment did not result in complete resolution of clinical RBD symptoms and polysomnographic (PSG) abnormalities. Our recent clinical epidemiologic study 8 found that 3.8% of psychiatric outpatients might have RBD features over the past year. The prevalence is 10 times more common than that of the typical RBD in the elderly general population. 9 In addition, the RBD features could result in sleep-related injuries and violence, with potential medicolegal repercussions. 8,10 In the current study, we conducted a comprehensive evaluation of clinical and PSG features as well as follow-up response to an open intervention of antidepressant regimen modification.Method. Fifteen depressed subjects with concurrent antidepressant treatment and features suggestive of RBD were included in this case series, which spans from December 2006 to March 2009. They were interviewed by experienced psychiatrists and neurologists for a thorough clinical evaluation, which included a semistructured psychiatric interview and physical examination with Hoehn and Yahr staging for parkinsonism. 11 They also underwent videopolysomnographic assessments at baseline and follow-up.Modification of their current antidepressant regimen was suggested to all subjects. Bupropion was offered as the treatment of choice in this open intervention, as it has rarely been associated

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supporting

confidence: 63%

REM Sleep Behavior Disorder in Psychiatric Populations

Lam¹,

Zhang²,

Tsoh³

et al. 2010

J. Clin. Psychiatry

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“…conflation of nightmare occurrences (Pagel & Helfter, 2003) and substantial levels of confounding sleep co-morbidities.…”

Section: Participantsmentioning

confidence: 99%

The unidirectional relationship of nightmares on self-harmful thoughts and behaviors.

Hochard¹,

Heym²,

Townsend³

2015

Dreaming

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Understanding the direction of the predictive relationship between nightmares and suicidal behaviors is important to model its underlying mechanisms. We examine the direction of this relationship and the mediating role of negative affect.A fixed interval diary study obtained pre-sleep and post-sleep measures of affect, nightmares, and self-harmful thoughts and behaviors (SHTBs) from 72 university students (88.9% This empirically validates assumptions of directionality for future models.

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“…Various neurotransmitter modulating systems have been implicated in the mechanisms of dreaming and in nightmares. Drugs affecting norepinephrine, serotonin, dopamine, acetylcholine and gamma-aminobutyric acid, such as b-blockers, antidepressants, dopamine agonists, anticholinergic agents and benzodiazepines, have more often been associated with nightmares [5].…”

mentioning

confidence: 99%