Drug-induced ototoxicity

Jp, Griffin

doi:10.3109/03005368809076453

Cited by 18 publications

(3 citation statements)

References 97 publications

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“…The ototoxicity of cis-platinum has been well documented, indeed it is the most potent ototoxic agent yet discovered (based upon equivalent inner ear fluid levels in animals); the literature has been reviewed by Moroso and Blair (1983), Koegel (1985) and Griffin (1988). Hearing loss, tinnitus and vestibular dysfunction have all been reported.…”

Section: Introductionmentioning

confidence: 99%

Ototoxicity of cis-platinum and its relationship to eye colour

1991

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The following hypothesis is presented: that the susceptibility of an individual patient to hearing loss as a result of cis-platinum administration can be predicted on the basis of eye colour. The rationale is that the melanin content of the inner ears is related to that of the eyes; dark eyes contain more melanin than lightcoloured eyes; and melanin causes the accumulation of the ototoxic drug within the inner ear. Hence those with dark eyes will suffer greater damage to the hearing than those with pale eyes. An investigation that confirmed this hypothesis is reported. In addition to cochlear damage there is a significant likelihood of damage to the auditory nerve as a result of the treatment.

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Section: Introductionmentioning

confidence: 99%

Ototoxicity of cis-platinum and its relationship to eye colour

1991

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“…Due to the animal's poor health status upon admission to the facility, the attending veterinarian administered ceftiofur, amikacin and enrofloxacin intramuscularly. Amikacin has known ototoxicity (Griffin, 1988;Tange, 1998), but it is unlikely that the drug would have had sufficient time to affect cochlear function prior to the time of testing. The animal died on 23 August 2017.…”

Section: Subjectsmentioning

confidence: 99%

Audiograms and click spectra of seven novel and seldom-tested odontocetes

et al. 2022

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The use of auditory evoked potentials has been promoted as a means by which to collect audiometric information from odontocete cetaceans that are rarely encountered in stranding situations. This article presents the results of auditory evoked potential hearing tests collected from stranded odontocetes over nearly a decade. For six species, no audiograms previously existed – the dwarf sperm whale (Kogia sima), pygmy sperm whale (Kogia breviceps), northern right whale dolphin (Lissodelphis borealis), melon-headed whale (Peponocephala electra), long-beaked common dolphin (Delphinus capensis), and Atlantic spotted dolphin (Stenella frontalis). Additional hearing information was gathered for the pygmy killer whale (Feresa attenuata), a species for which only two prior audiograms had been collected. Audiograms for the delphinids demonstrated a typical dolphin-like form with upper-frequency limits of hearing > 149 kHz, except for the pygmy killer whales whose upper-frequency limit was between 103-107 kHz. The kogiid audiograms had a narrower region of increased sensitivity (80-128 kHz) closely aligned with their narrowband, high-frequency echolocation signals. Distinctions between kogiids and delphinids existed in the latencies of peaks of click-evoked auditory brainstem responses, with longer interwave intervals between P4 and N5 in the kogiids (mean of 0.60 ms vs. a mean of 0.37 ms in the delphinids). Modulation rate transfer functions collected in three of the species, suggested group-wide similarities in temporal processing capabilities.

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“…There is also a n increasing awareness that effects of noise or exposure to sound can be exacerbated by ototoxic agents (McFadden, 1986;Bancroft et al, 1989). Among ototoxic drugs, the largest class is that of aminoglycoside antibiotics, such as streptomycin, kanamycin, and gentamicin (Harpur, 1982;Griffin, 1988). These drugs are widely employed because of their clinical efficacy, but in the process may cause considerable ototoxicity (Hodges, 1984;Koegel, 1985).…”

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confidence: 99%

Potentiation of cochlear hair cell loss by acoustic stimulus and gentamicin in the guinea pig

Bhattacharyya

Dayal

1991

Anat. Rec.

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We explored the possibility of synergism between a pure-tone stimulus and gentamicin in causing cochlear injury by analyzing hair cell loss. Guinea pigs receiving daily injections of gentamicin (200 mg/kg body wt.) for 1 week were exposed to a 2 kHz tone (95 dB SPL, 2 hours daily). Surface preparations of the spiral organ were studied by phase contrast microscopy, and the extent of hair cell loss in the entire organ of Corti was recorded in cytocochleograms. Gentamicin by itself was slightly ototoxic, damaging the innermost row of outer hair cells, whereas exposure to sound alone caused no hair cell loss. Combined antibiotic and acoustic exposure produced extensive cochlear damage. A few animals showed massive hair cell degeneration and collapse of the organ of Corti, except in the apical turn. The site of damage was possibly determined by the frequency of the sound stimulus. Thus, an intermittent tonal stimulus such as that used in the present experiment can be harmless by itself, but causes injury to cochlear hair cells in guinea pigs when administered in combination with gentamicin.

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Drug-induced ototoxicity

Cited by 18 publications

References 97 publications

Ototoxicity of cis-platinum and its relationship to eye colour

Ototoxicity of cis-platinum and its relationship to eye colour

Audiograms and click spectra of seven novel and seldom-tested odontocetes

Potentiation of cochlear hair cell loss by acoustic stimulus and gentamicin in the guinea pig

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