Drug induced parkinsonism

Hirose, Genjiro

doi:10.1007/s00415-006-3004-8

Cited by 28 publications

(45 citation statements)

References 13 publications

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“…Several risk factors have been suggested to predispose to AIP, such as old age, female gender, and high doses of antipsychotics [Metzer et al, 1989;Ebadi and Srinivasan, 1995;Caligiuri et al, 1999Caligiuri et al, , 2000Jabs et al, 2003;Hirose, 2006]. However, these factors only partially explain the variance in the occurrence of AIP and hereditary predisposition is, therefore, possible [Galdi et al, 1981;Lencer et al, 2004].…”

Section: Introductionmentioning

confidence: 93%

“…Antipsychotic-induced parkinsonism (AIP) is an acute movement disorder that may appear in 15-40% of patients within the first few weeks following the start of an antipsychotic and may adversely affect therapeutic compliance, self-esteem, and quality of life [Fleischhacker et al, 1994;Gerlach, 1999;Hofer et al, 2004;Hirose, 2006]. Several risk factors have been suggested to predispose to AIP, such as old age, female gender, and high doses of antipsychotics [Metzer et al, 1989;Ebadi and Srinivasan, 1995;Caligiuri et al, 1999Caligiuri et al, , 2000Jabs et al, 2003;Hirose, 2006].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African‐Caribbean inpatients: Differences in association with dopamine and serotonin receptors

Hadithy

Wilffert

Stewart

et al. 2008

American J of Med Genetics Pt B

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We studied the association between polymorphisms of genes coding for dopamine D(2) (DRD2), dopamine D(3) (DRD3), serotonin 2(a) (HTR2A), and serotonin 2(c) (HTR2C) receptors and Antipsychotic-Induced Parkinsonism (AIP), rigidity, bradykinesia, and rest-tremor in African-Caribbeans treated with antipsychotics. Polymorphisms of DRD2 (-141CIns/Del, TaqIA, 957C > T), DRD3 (Ser9Gly), HTR2A (-1438A > G, 102T > C, His452Tyr), and HTR2C (-759C > T, Cys23Ser) genes were determined according to standard protocols. The Unified Parkinson Disease Rating Scale was used for the measurement of AIP, rigidity, bradykinesia, and rest-tremor. Chi-squared or Fisher's exact tests were applied for the association analyses. The t-test was applied for continuous data. Ninety nine males and 27 females met the inclusion criteria (Schizophr Res 1996, 19:195). In males, but not in females, there were significant associations between -141CDel-allele carriership (DRD2) and rigidity (Fisher's Exact Test: P = 0.021) and between 23Ser-allele carriership (HTR2C) and bradykinesia (P = 0.026, chi(2) = 5.0) or AIP (P = 0.008, chi(2) = 7.1). Rest-tremor was not associated with any of the polymorphisms studied. Analyses of the age, chlorpromazine equivalents, benztropine equivalents, the number of patients using anticholinergic medication, and the utilization patterns of the antipsychotic medication did not show statistically significant differences between patients with and without AIP, rigidity, bradykinesia, rest-tremor. Conducting the analysis without gender stratification did not affect our findings considerably, except for the association between bradykinesia and 23Ser-allele which failed to reach statistical significance in the total sample (P = 0.0646, chi(2) = 3.41). Since AIPs subsymptoms (rigidity, bradykinesia, and rest-tremor) may differ pharmacogenetically, our data strongly support symptom-specific analysis of AIP. However, further research is warranted to confirm our findings.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African‐Caribbean inpatients: Differences in association with dopamine and serotonin receptors

Hadithy

Wilffert

Stewart

et al. 2008

American J of Med Genetics Pt B

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“…Several risk factors have been suggested to predispose to AIP such as old age, female gender, high antipsychotic dose, and hereditary predisposition (Al Hadithy et al, 2008;Caligiuri et al, 1999;Hirose, 2006;Jabs et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Lack of association between antipsychotic‐induced Parkinsonism or its subsymptoms and rs4606 SNP of RGS2 gene in African‐Caribbeans and the possible role of the medication: The Curacao extrapyramidal syndromes study X

Hadithy¹,

Wilffert²,

Bruggeman³

et al. 2009

Human Psychopharmacology

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Recent studies demonstrate an association between antipsychotic-induced parkinsonism (AIP) and rs4606 SNP of RGS2 gene in Jewish and African-Americans. The current study investigates the association between rs4606 and AIP or its subsymptoms (rest tremor, rigidity, and bradykinesia) in 112 psychiatric inpatients of African-Caribbean origin. Presence of AIP, rigidity, bradykinesia, and tremor was measured by the UPDRS. We applied chi(2) (or Fisher Exact) and logistic regression analyses in several models including rs4606, age, gender, dose of antipsychotics, and anticholinergics, and two other putatively functional SNPs in DRD2 (-141CIns/Del) and HTR2C (Cys23Ser) genes. In contrast to recent literature, we find no evidence for an association between rs4606 and AIP or any of its subsymptoms. We hypothesize that the observed lack of association is due probably to differences in serotonin 2A-receptor affinities of the antipsychotics utilized (in contrast to the other published studies, the majority of our patients utilized typical antipsychotics).

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“…5 AIP mimics idiopathic Parkinson's disease symptoms such as bradykinesia and rigidity, but tremor is reported to be less frequent. 5 About two-thirds of the patients recover within 2 months but some may require over 6 months for their parkinsonism to resolve. 1 AIP is also observed as a late onset (tardive) manifestation.…”

Section: Introductionmentioning

confidence: 99%

“…6 Risk factors for AIP include older age, female gender and the use of antipsychotic drugs that block the dopamine D2 receptor with a high level of potency. 5 Genetic factors may contribute to inter-individual differences in susceptibility. 7 Recently, we reported association of the regulator of G-protein signaling 2 gene (RGS2) with susceptibility to AIP in patients with schizophrenia treated with antipsychotic drugs.…”

Section: Introductionmentioning

confidence: 99%

Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3′-untranslated region

Greenbaum¹,

Smith

Rigbi³

et al. 2008

Pharmacogenomics J

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RGS2 (regulator of G-protein signaling 2) modulates dopamine receptor signal transduction. Functional variants in the gene may influence susceptibility to extrapyramidal symptoms (EPS) induced by antipsychotic drugs. To further investigate our previous report of association of the RGS2 gene with susceptibility to antipsychotic-induced EPS, we performed a replication study. EPS were rated in 184 US patients with schizophrenia (115 African Americans, 69 Caucasian) treated for at least a month with typical antipsychotic drugs (n ¼ 45), risperidone (n ¼ 46), olanzapine (n ¼ 50) or clozapine (n ¼ 43). Six single nucleotide polymorphisms (SNPs) within or flanking RGS2 were genotyped (rs1933695, rs2179652, rs2746073, rs4606, rs1819741 and rs1152746). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. Our results indicate association of SNP rs4606 with antipsychotic-induced parkinsonism (AIP), as measured by the Simpson Angus scale, in the overall sample and in the African-American subsample, the G (minor) allele having a protective effect. ORs for AIP among rs4606 G-allele carriers were 0.23 (95% CI 0.10-0.54, P ¼ 0.001) in the overall sample, and 0.20 (0.07-0.57, P ¼ 0.003) in the African-American subsample. In the previously studied Israeli sample the OR was 0.31 (0.11-0.84, P ¼ 0.02). We completely sequenced the RGS2 gene in nine patients with AIP and nine patients without, from the Israeli sample. No common coding polymorphisms or additional regulatory variants were revealed, suggesting that association of the rs4606 C/G polymorphism with AIP is biologically meaningful and not a consequence of linkage disequilibrium with another functional variant. Taken together, the findings of the current study support the association of RGS2 with AIP and focus on a possible protective effect of the minor G allele of SNP rs4606. This SNP is located in the 3 0 -regulatory region of the gene, and is known to influence RGS2 mRNA levels and protein expression.

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Drug induced parkinsonism

Cited by 28 publications

References 13 publications

Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African‐Caribbean inpatients: Differences in association with dopamine and serotonin receptors

Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African‐Caribbean inpatients: Differences in association with dopamine and serotonin receptors

Lack of association between antipsychotic‐induced Parkinsonism or its subsymptoms and rs4606 SNP of RGS2 gene in African‐Caribbeans and the possible role of the medication: The Curacao extrapyramidal syndromes study X

Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3′-untranslated region

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