Drug‐induced parkinsonism: a review

Jl, Montastruc; Llau, M E; Rascol, Olivier; Senard, Jean‐Michel

doi:10.1111/j.1472-8206.1994.tb00808.x

Cited by 101 publications

(38 citation statements)

References 108 publications

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“…In addition, gender-related differences are a common feature of the pharmacological properties of most centrally active drugs (19)(20)(21); for instance, drug-induced parkinsonism in humans exhibits a femaleto-male predominance ratio of about 2:1 (22). Nevertheless, there is no information concerning gender dimorphism in the effects of nitrergic agents on the phenomenon of neuroleptic-induced catalepsy.…”

Section: Introductionmentioning

confidence: 98%

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Pires

Costa

Saraiva

et al. 2003

Braz J Med Biol Res

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It has been suggested that nigrostriatal dopaminergic transmission is modulated by nitric oxide (NO). Since there is evidence that gonadal hormones can affect extrapyramidal motor behavior in mammals, we investigated the effects of isosorbide dinitrate (ISD), linsidomine (SIN-1) and S-nitroso-N-acetylpenicillamine (SNAP), three pharmacologically different NO donors, on neuroleptic-induced catalepsy in 60-to 80-day-old male and female albino mice. Catalepsy was induced with haloperidol (1 mg/kg, ip) and measured at 30-min intervals by means of a bar test. Drugs (or appropriate vehicle) were injected ip 30 min before haloperidol, with each animal being used only once. ISD (5, 20 and 50 mg/kg) caused a dose-dependent inhibition of catalepsy in male mice (maximal effect 120 min after haloperidol: 64% inhibition). In the females only at the highest dose of ISD was an attenuation of catalepsy observed, which was mild and short lasting. SIN-1 (10 and 50 mg/kg) did not significantly affect catalepsy in female mice, while a significant attenuation was observed in males at the dose of 50 mg/kg (maximal inhibition: 60%). SNAP (20 mg/kg) significantly attenuated catalepsy in males 120 min after haloperidol (44% inhibition), but had no significant effect on females. These results basically agree with literature data showing that NO facilitates central dopaminergic transmission, although the mechanisms are not fully understood. They also reveal the existence of gender-related differences in this nitrergic modulation in mice, with females being less affected than males. Correspondence

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Section: Introductionmentioning

confidence: 98%

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Pires

Costa

Saraiva

et al. 2003

Braz J Med Biol Res

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“…Drug-induced parkinsonism (DIP) is a common movement disorder [5] caused by drugs affecting dopamine receptors [6][7][8]. While TMZ was found to be generally well tolerated in clinical trials, a number of recent studies have reported parkinsonism symptoms and exacerbation of Parkinson's disease as adverse drug reactions related to treatment with TMZ.…”

Section: Introductionmentioning

confidence: 99%

Association between Trimetazidine and Parkinsonism: A Population-Based Study

Kwon

Kim

et al. 2019

Neuroepidemiology

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Background: The prevalence of drug-induced parkinsonism (DIP) has been reported with the use of trimetazidine (TMZ), an antianginal medication available in Asian and European countries. Very few studies have evaluated the association between DIP and TMZ use, and studies using population-based data from national databases are lacking. Objectives: To investigate the association between DIP and use of TMZ in patients with angina using data from a national healthcare claims database and to determine the predictive factors of DIP in TMZ use. Methods: A cross-sectional study was conducted on patients aged 40 years or more diagnosed with angina, using the Korean National Healthcare claims 2014 database. The association between TMZ use and DIP was evaluated using multivariate logistic regression analysis, adjusting for confounders, including age; sex; insurance type; comorbidities; and concurrent medications known to be commonly associated with DIP, such as typical and atypical antipsychotics. Results: Of the patients included in the study, 19% were prescribed TMZ. In addition, 2.5% of TMZ users had preexisting extrapyramidal and movement disorders. TMZ use was found to be a significant predictor of a new diagnosis of parkinsonism (adjusted OR [aOR] 1.39; 95% CI 1.06–1.81; p = 0.016). Age ≥65 years (aOR 2.07; 95% CI 1.13– 3.74; p = 0.017) and stroke as comorbid disease (aOR 3.23; 95% CI 1.87–5.61; p < 0.001) were also significantly associated with a new diagnosis of parkinsonism in TMZ users. Conclusions: Treatment with TMZ was a statistically significant predictor of a new diagnosis of parkinsonism. Efforts should focus on close monitoring of, and education on, TMZ use in relation to DIP in all patients who are prescribed TMZ, including those with preexisting extrapyramidal and movement disorders.

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“…On the other hand, drug-induced parkinsonism is frequently indistinguishable from idiopathic parkinsonism [8]. Several cases have been described where drug-induced parkinsonism first appears and subsequently idiopathic parkinsonism is diagnosed [9].…”

Section: Importance Of the Husband-wife Concordance Of Pdmentioning

confidence: 99%

Null Hypothesis of Husband-Wife Concordance of Parkinson’s Disease in 1,000 Married Couples Over Age 50 in Spain

Ubeda

1998

Neuroepidemiology

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While the search for environmental neurotoxins as causal factors of Parkinson’s disease (PD) continues, we have found no concordance in 1,000 married couples over age 50 in Spain. In addition, it has been possible to identify a structural grouping of similar chemical characteristics that is repeated in the majority of organic compounds that can induce parkinsonism. These compounds have a structural relationship with the dopamine molecule. The principal epidemiological aspects of PD have a preliminary rational explanation.

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Drug‐induced parkinsonism: a review

Cited by 101 publications

References 108 publications

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Association between Trimetazidine and Parkinsonism: A Population-Based Study

Null Hypothesis of Husband-Wife Concordance of Parkinson’s Disease in 1,000 Married Couples Over Age 50 in Spain

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