Drug-induced retroperitoneal fibrosis: a case/non-case study in the French PharmacoVigilance Database

Abstract

The data that support the findings of this study are available from the corresponding author upon reasonable request.

New‐onset retroperitoneal fibrosis following COVID‐19 mRNA vaccination: Coincidental or vaccine‐induced phenomenon?

“…While the causal relationship has not been completely determined, post-COVID-19 mRNA vaccine autoimmune phenomena, including immune thrombocytopenic purpura, 1 autoimmune hepatitis, 13 and systemic lupus erythematosus, 4 have been reported. We hypothesized that the RPF in our case was associated with Pfizer BioNTech Drug-associated RPF has been reported with methyldopa, likely through a dysregulated immune response 14 with methysergide, through serotonin-induced transforming growth factorβ-mediated myofibroblast proliferation, 10 and with tumor necrosis factorα (TNFα) inhibitors, through unclear but possibly immune-mediated mechanisms. 10 Likewise, the Pfizer BioNTech COVID-19 mRNA vaccine may lead to RPF through autoimmunity-inducing mechanisms.…”

“…We hypothesized that the RPF in our case was associated with Pfizer BioNTech Drug-associated RPF has been reported with methyldopa, likely through a dysregulated immune response 14 with methysergide, through serotonin-induced transforming growth factorβ-mediated myofibroblast proliferation, 10 and with tumor necrosis factorα (TNFα) inhibitors, through unclear but possibly immune-mediated mechanisms. 10 Likewise, the Pfizer BioNTech COVID-19 mRNA vaccine may lead to RPF through autoimmunity-inducing mechanisms. After the vaccination, a proinflammatory immune response may target self-antigens through the bystander effect; 5 this may initiate RPF because antigen presentation to adventitial CD4 + T cells is the core of its pathogenesis, although no specific antigen has been identified.…”

“…Drug‐associated RPF has been reported with methyldopa, likely through a dysregulated immune response 14 with methysergide, through serotonin‐induced transforming growth factor‐β‐mediated myofibroblast proliferation, 10 and with tumor necrosis factor‐α (TNF‐α) inhibitors, through unclear but possibly immune‐mediated mechanisms 10 . Likewise, the Pfizer BioNTech COVID‐19 mRNA vaccine may lead to RPF through autoimmunity‐inducing mechanisms.…”

“…7 The pathogenesis of RPF starts through antigen presentation to adventitial CD4 + T cells followed by cytokine release, including IL-6, which plays a role in B-cell activation and fibroblast proliferation. 8 Idiopathic RPF constitutes two-thirds of RPF cases, 10 but the rest are secondary to either drugs, malignancies, 11,12 or infections. 7 Herein, we report a case of RPF possibly associated with the Pfizer BioNTech COVID-19 mRNA vaccine.…”

The Onset of IgG4-related Retroperitoneal Fibrosis under Administration of a TNF Inhibitor in a Rheumatoid Arthritis Patient

“…From the point of view of drug-induced diseases, RPF can be caused by hypnotics, antiepileptic drugs, antipsychotics, and TNF inhibitors ( 11 ). According to Brasselet's report, only etanercept was able to induce drug-induced RPF among the drugs administered to our patient.…”