Drug-induced rhabdomyolysis

Coco, Teresa; Klasner, Ann E.

doi:10.1097/00008480-200404000-00017

Cited by 116 publications

(93 citation statements)

References 14 publications

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“…Serum CK concentration begins to increase 2-12 h after the initial muscle injury and will peak between 3 and 5 days. This means that at the beginning of rhabdomyolysis serum CK may be normal [4]. Our patient showed a biphasic serum CK elevation.…”

Section: Figurementioning

confidence: 53%

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Biphasic creatine kinase elevation in pseudoephedrine overdosage

Gülhan

Bayrakçı

Babaoğlu

et al. 2008

Brit J Clinical Pharma

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Section: Figurementioning

confidence: 53%

“…Drugs and toxins are also important causes of rhabdomyolysis in both adults and children. More than 150 drugs and toxins have been reported to cause rhabdomyolysis [4]. Other aetiologies in children include anoxic-ischaemic encephalopathy, electrolyte disorders, severe hyperthermia and hereditary myopathies [5].…”

mentioning

confidence: 99%

Biphasic creatine kinase elevation in pseudoephedrine overdosage

Gülhan

Bayrakçı

Babaoğlu

et al. 2008

Brit J Clinical Pharma

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“…This may augment muscle contraction and increase energy demands that could resulted cell destruction. Consequently, such victim"s rhabdomyolysis was most likely due to direct toxicity that caused increased muscular activity and injury [27] . M. Hayot, E. Barreiro, A. Perez, G. Czaika, et al (2001) during studying the in vitro mechanism of skeletal muscles injury and repair the researchers utilized caffeine solution at different exposure time as an agent to create a pattern of skeletal muscles injury [28] and this finding greatly indicate that high dose caffeine targeting skeletal muscles causing these myocytes to be injured which agreed with the…”

Section: Resultsmentioning

confidence: 99%

Possible Toxic Effects of Different Oral Doses of Caffeine on the Skeletal Muscles in Healthy Adult Albino Rats: Biochemical Assessments

2017

ARC Journal of Pharmaceutical Sciences

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“…Drug-induced rhabdomyolysis can be primary due to myotoxic effect or secondary when local muscle compression occurs in coma. 9 Ethanol, drugs of abuse, and statins are commonly implicated.…”

Section: Etiopathogenesismentioning

confidence: 99%

Bilateral Atraumatic Compartment Syndrome of the Legs Leading to Rhabdomyolysis and Acute Renal Failure Following Prolonged Kneeling in a Heroin Addict. A Case Report and Review of Relevant Literature

Biswas¹,

Rao²,

Duckworth³

et al. 2013

Panamerican Journal of Trauma, Critical Care &Amp; Emergency Surgery

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Introduction Compartment syndrome is defined as a symptom complex caused by increased pressure of tissue fluid in a closed osseofascial compartment which interferes with circulation to the myoneural components of the compartment. Bilateral compartment syndrome of the legs is a rare presentation requiring emergent surgical intervention. In a recent case report (Khan et al 2012) there have been only eight reported cases cited with bilateral compartment syndrome. Heroin abuse is known to cause compartment syndrome, traumatic and atraumatic rhabdomyolysis. Hypothyroidism can also independently present with rhabdomyolysis. Case presentation We present a case of a 22 years old female who presented with bilateral swelling of the legs with associated loss of sensation having spent two days kneeling against the wall following IV heroin abuse. She presented to the emergency department with bilateral swelling of the legs with loss of sensation. She was diagnosed with compartment syndrome requiring emergent bilateral 4 compartment fasciotomy of the lower extremities. Inspite of aggressive fluid resuscitation she developed rhabdomyolysis complicated by acute renal failure requiring dialysis. She made a full recovery with full return of her renal as well as motor and sensory function. Conclusion We discuss this interesting case of bilateral compartment syndrome in a heroin abusive patient with history of hypothyroidism complicated by rhabdomyolysis and acute renal failure. There have been isolated case reports of bilateral compartment syndrome following prolonged surgery. High index of suspicion, early recognition and therapeutic intervention is the key to good outcome. We discuss the etiopathology and management options of rhabdomyolysis. Treating the comorbities like hypothyroidism is also important for the recovery. How to cite this article Biswas S, Rao RS, Duckworth A, Kothuru R, Flores L, Abrol S. Bilateral Atraumatic Compartment Syndrome of the Legs Leading to Rhabdomyolysis and Acute Renal Failure Following Prolonged Kneeling in a Heroin Addict. A Case Report and Review of Relevant Literature. J Trauma Critical Care Emerg Surg 2013;2(3):139-145.

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Drug-induced rhabdomyolysis

Abstract: A high index of suspicion, early recognition, and adequate treatment will result in an excellent prognosis of drug-induced rhabdomyolysis.

Cited by 116 publications

References 14 publications

Biphasic creatine kinase elevation in pseudoephedrine overdosage

Biphasic creatine kinase elevation in pseudoephedrine overdosage

Possible Toxic Effects of Different Oral Doses of Caffeine on the Skeletal Muscles in Healthy Adult Albino Rats: Biochemical Assessments

Bilateral Atraumatic Compartment Syndrome of the Legs Leading to Rhabdomyolysis and Acute Renal Failure Following Prolonged Kneeling in a Heroin Addict. A Case Report and Review of Relevant Literature

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