Drug-Induced Sexual Dysfunction

McWaine, Duane E.; Procci, Warren R.

doi:10.1007/bf03259941

Cited by 12 publications

(6 citation statements)

References 90 publications

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“…In this article, we update information given in an earlier review of drug-induced sexual dysfunction (McWaine & Procci 1988). Recent advances made in sexual physiology are highlighted and an outline describing our diagnostic and treatment approach is presented.…”

Section: Discussionmentioning

confidence: 97%

“…Recent work has shown that variable inhibition of the reuptake of noradrenaline and serotonin can be seen with the different heterocyclic agents based on their chemical configuration (McWaine & Procci 1988;Wein & van Arsdalen 1988). Recent work has shown that variable inhibition of the reuptake of noradrenaline and serotonin can be seen with the different heterocyclic agents based on their chemical configuration (McWaine & Procci 1988;Wein & van Arsdalen 1988).…”

Section: Antidepressantsmentioning

confidence: 99%

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Drug-Induced Male Sexual Dysfunction

Brock

Lue

1993

Drug Safety

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Impotence, defined as the consistent inability to maintain an erect penis of sufficient rigidity for sexual intercourse, has been estimated to affect 10 million American men. An age dependence has been shown to exist, with 25% of men over age 65 affected. A large body of clinical experience and published reports in the literature link many commonly prescribed drugs with sexual dysfunction. Drugs can affect sexual function at a variety of points such as inhibition of ejaculation or sedation/depression leading to reduced libido. Antihypertensive drugs have been most commonly associated with impotence. There have been reports of sexual dysfunction with almost all classes of antipsychotics, but little clinical investigation has been performed. Other drugs associated with sexual dysfunction include digoxin, clofibrate, cimetidine and various hormonal agents and antineoplastics. An important first step in approaching all impotent patients is the taking of a detailed medical, surgical, sexual and drug/substance abuse history. The least invasive form of therapy should be employed. Recent studies have shown intracavernous injections of alprostadil (prostaglandin E1) to be safe and effective for long term use. Vacuum constriction devices may also be of help. Better and more durable prostheses are now available should other treatment be unsuccessful.

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Section: Discussionmentioning

confidence: 97%

Section: Antidepressantsmentioning

confidence: 99%

Drug-Induced Male Sexual Dysfunction

Brock

Lue

1993

Drug Safety

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“…Examples of drugs implicated as a cause of ED include hydrochlorothiazides and beta-blocking agents. Medications used to treat depression, particularly the SSRIs such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Prozac Weekly, Sarafem), fluvoxamine (Luvox, Luvox CR), paroxetine (Paxil, Paxil CR, Pexeva) and sertraline (Zoloft), may also contribute to ED 9. Bupropion (Wellbutrin) which has a predominant effect on blocking the reuptake of dopamine is an antidepressant with lower incidence of ED 10.…”

Section: Overview Of Physiological Changes and Other Risk Factorsmentioning

confidence: 99%

Recent advances in the treatment of erectile dysfunction

Mobley

Khera

Baum

2017

Postgraduate Medical Journal

124

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Erectile dysfunction (ED) is one of the most common conditions affecting middle-aged and older men. Nearly every primary care physician, internist and geriatrician will be called upon to manage this condition or to make referrals to urologists, endocrinologists and cardiologists who will assist in the treatment of ED. This article will briefly discuss the diagnosis and management of ED. In addition, emerging concepts in ED management will be discussed, such as the use of testosterone to treat ED, the role of the endothelium in men with ED and treating the partner of the man with ED. Finally, future potential therapies for ED will be discussed.

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“…8,9 SD has also been attributed to other physical, clinical factors and psychological factors. 5,[10][11][12][13][14][15][16][17][18][19] Research on erectile dysfunction patients indicate that SD has significant adverse effects on both physical and mental health dimensions of quality of life (QOL). [20][21][22][23][24] Sexual dysfunction data for Asian populations are scant and primarily clinic-based.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

2005

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The prevalence of sexual problems (SP) and sexual satisfaction and their associations with sexrelated perceptions and quality of life (QOL) were investigated by interviewing 3257 and 1568 Chinese adults in Hong Kong by a specially designed computerized telephone-interviewing method. SP was prevalent among male (50.9%) and female (54%) respondents; approximately 50% were dissatisfied with their sexual life. Of respondents, 23.9% of men and 5.9% of women perceived sex as important and 52.5% for men and 33.8% of women reported adequate sexual knowledge. The prevalence of SP ranged from 3.4% (pain) to 29.7% (premature orgasm) for men and 6.9% (anxiety) to 24.7% (lack of interest) for women. Prevalence of erectile and lubrication problems were 9.6 and 23.6%, respectively. Sex-related knowledge, perceived importance of sex, perceived physical health status, sexual satisfaction were predictors of SP. Gender differences and strong cultural influences appear to exist. Moreover, SP and sexual satisfaction were associated with mental health and vitality QOL and overall life satisfaction. IntroductionRecent studies have showed that sexual dysfunctions are common in both sexes. [1][2][3][4] A study in the US estimated the prevalence of sexual dysfunction (SD) to be 43% among women and 31% among men. 5 An analysis of 22 general population surveys conducted in western countries summarized estimates of SD prevalence for men (inability to achieve orgasm: 5%, premature ejaculation: 35%, inhibited sexual excitement: 10-20% and inhibited sexual desire: 1-15%) and for women (inability to achieve orgasm: 5-30% and inhibited sexual desire: 1-35%). 6 Similarly, a large-scale international collaboration of multidisciplinary experts reported that 40-45% of adult women and 20-30% of adult men suffer from at least one SD. 7 It also reported the following prevalence rates among women: low levels of sexual interest at 17-55%, lubrication difficulties about 8-15%, orgasmic dysfunction at 25% and vaginismus at approximately 6%. The prevalence of erectile dysfunction was reported to be 1-9% among young males under 40 y old and rapidly increased with age to 20-40% among males between the ages of 60-69 y. 7 Age, lower education, socioeconomic status, perceived health, diabetes, heart disease and hypertension were found to be important determinants of erectile dysfunction in men. 8,9 SD has also been attributed to other physical, clinical factors and psychological factors. 5,[10][11][12][13][14][15][16][17][18][19] Research on erectile dysfunction patients indicate that SD has significant adverse effects on both physical and mental health dimensions of quality of life (QOL). [20][21][22][23][24] Sexual dysfunction data for Asian populations are scant and primarily clinic-based. [25][26][27][28][29][30] Moreover, little is known about the prevailing attitudes and perceptions of sexual problems (SP) or its effects on QOL in Asian populations. Few large-scale, population-based studies on SP have been reported in Chinese population study. The study i...

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Drug-Induced Sexual Dysfunction

Cited by 12 publications

References 90 publications

Drug-Induced Male Sexual Dysfunction

Drug-Induced Male Sexual Dysfunction

Recent advances in the treatment of erectile dysfunction

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

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