Drug-Induced Takotsubo Cardiomyopathy

Abstract

Our systematic review showed that over two-thirds of drug-induced TCM cases were due to direct or indirect catecholamine stimulation. The lowest effective dose and shortest duration of catecholamines should be utilized, and alternative therapies should be considered if feasible.

The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload

“…Despite the abovementioned conflicting results, TTS has been induced in several clinical cases by the intravenous injection of catecholamines. In 2017, Kido and Guglin analyzed 157 cases of drug-induced TTS and found that 68.2% were catecholamines-related, while 8.9% appeared to be associated with chemotherapy-induced coronary vasospasm [25]. In addition, Abraham et al revealed in 2009 that the intravenous administration of epinephrine or beta-receptor agonists could induce all the characteristic features of TTS, including an elevation of cardiac isoenzyme levels, rapidly reversible cardiac dysfunction, and QTc interval prolongation [26].…”

Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy

“…106 The protein product of PIK3R3 , phosphoinositide-3-kinase regulatory subunit 3, acts downstream of G-protein-coupled receptors in cardiac function, 107 and is also a target for isoproterenol, which can trigger SCM-like conditions in humans and rodents. 12; 108–110…”

Reverse Takotsubo cardiomyopathy after intravenous glycopyrrolate administration postpartum

“…The pathophysiology of Takotsubo cardiomyopathy remains unknown, as does the optimal treatment strategy. 3 Direct and indirect catecholamine stimulation has been associated with its development and progression, 4 supporting the hypothesis that excessive sympathetic stimulation is fundamental to the pathophysiology of the disease. 3 Why certain individuals are susceptible to this process is unclear, as is whether primary pathology or susceptibility resides in the brain, the autonomic nervous system, the myocardium, or all three.…”