Drug-induced taste disorders

Naik, Bitan; Shetty, Nagaraja; Maben, E.V.S.

doi:10.1016/j.ejim.2010.01.017

Cited by 79 publications

(67 citation statements)

References 18 publications

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“…Subjects were not medication free, especially in the autism group. Because of potential association with medication taking and olfactory abilities, we performed a literature search and found only minimal effects of antipsychotic and other psychotropic medications on olfactory performance [5,19,36,37]. There was also a high rate of allergies in both groups that corresponded with the use of anti-allergy medication.…”

Section: Discussionmentioning

confidence: 99%

Odor detection threshold, but not odor identification, is impaired in children with autism

Dudová

Vodička

Havlovičová

et al. 2011

Eur Child Adolesc Psychiatry

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Objective: The aim of our study was to examine odor detection thresholds and odor identification in autistic subjects. Methods:Thirty-five patients with Asperger"s syndrome and high functioning autism (mean age 10.8 ± 3.6 years; 31 boys) were compared with 35 healthy control subjects (mean age 10.4 ± 2.4 years; 28 boys). There were no significant differences between groups with regard to mean age (p = 0.598) and gender proportion (p = 0.324). Olfactory testing used the Sniffin" Sticks test (Threshold and Identification parts only).Results: Participants with Asperger"s syndrome and high functioning autism, in comparison with healthy controls, were significantly impaired relative to odor detection thresholds (6.3 ± 3.1 vs. 7.9 ± 2.0; p = 0.025). Autistic participants were significantly better in correctly identifying the odor of an orange (94% vs. 63%; p < 0.05) and significantly worse at correctly identifying the odor of cloves (40% vs. 74%; p < 0.05). With regard to identification of fourteen other substances, there were no significant differences. There was no significant difference between autistic and control subjects on the total score of olfactory identification (p = 0.799). Odor identification ability (as expressed by this total score) correlated significantly with age in the control group (p = 0.049) but not in the autism group (p = 0.103). Conclusions:We found impaired odor detection and almost normal odor identification in children with autism. Implications for further research are discussed.

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Section: Discussionmentioning

confidence: 99%

Odor detection threshold, but not odor identification, is impaired in children with autism

Dudová

Vodička

Havlovičová

et al. 2011

Eur Child Adolesc Psychiatry

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“…Appetite-affecting medications include antianxiety agents, antibacterials, antidepressants, antiepileptics, antifungals, antihistamines and decongestants, antihypertensives and cardiac medications, anti-inflammatory, antimigraine, antineoplastics, antiparkinsonic and antiviral agents, bronchodilators, CNS stimulants, hypnotics, lipid-lowering agents, muscle relaxants, pancreatic enzyme preparations, smoking cessation aids, and thyroid drugs. A detailed list of these medications and a review of mechanisms involved in drug-induced taste disorders was published by Naik et al (2010).…”

Section: Medicationsmentioning

confidence: 99%

Mechanisms of the anorexia of aging—a review

Wysokiński

Sobów

Kłoszewska

et al. 2015

AGE

189

148

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Many, even healthy, older people fail to adequately regulate food intake and experience loss of weight. Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The etiology of the anorexia of aging is multi-factorial and includes a combination of physiological changes associated with aging (decline in smell and taste, reduced central and peripheral drive to eat, delayed gastric emptying), pathological conditions (depression, dementia, somatic diseases, medications and iatrogenic interventions, oral-health status), and social factors (poverty, loneliness). However, exact mechanisms of the anorexia of aging remain to be elucidated. Many neurobiological mechanisms may be secondary to age-related changes in body composition and not associated with anorexia per se. Therefore, further studies on pathophysiological mechanisms of the anorexia of aging should employ accurate measurement of body fat and lean mass. The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality. Since this symptom can lead to dramatic consequences, early identification and effective interventions are needed. One of the most important goals in the geriatric care is to optimize nutritional status of the elderly.

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“…Suspected drug's dose should either be reduced or the drug use must be stopped and special attention must be given to oral hygiene. Treatment of an existing zinc deficiency and alpha lipoic acid treatment have been shown to be useful in some cases (10).…”

Section: Discussionmentioning

confidence: 99%

“…Taste disorder is the most commonly seen and equally overlooked side effect of the ACE inhibitors. Captopril may cause many taste disorders including altering sweet and salty tastes, inducing a metallic and bitter taste in the mouth (10,11).…”

Section: Discussionmentioning

confidence: 99%