Drug-Induced Thrombocytopenia

Abstract

Many reports of drug-induced thrombocytopenia do not provide evidence supporting a definite or probable causal relation between the disease and the drug. Future patient case reports should incorporate standard criteria to clearly establish the etiologic role of the drug.

Probable Etoricoxib-Induced Severe Thrombocytopenia: A Case Report

“…Drug-dependent antiplatelet antibody assays, where available, are not well standardized [7]. Ultimately the diagnosis of drug-induced thrombocytopenia is by exclusion [8].…”

“…Ultimately the diagnosis of drug-induced thrombocytopenia is by exclusion [8]. The primary treatment for DITP is to discontinue the suspected drug [7]. Patients at risk of life-threatening bleeding may benefit from intravenous immunoglobulin therapy, plasmapheresis and platelet transfusion.…”

A Novel Association between Antiretroviral Therapy and Drug-Induced Immune Thrombocytopenia Purpura

“…Current understanding of pathogenesis is lacking with several mechanisms described for different medications [2]. Criteria have been published to evaluate potential causality for drugs implicated in DITP [3]. In our study patient, the medication fulfilled 3 of 4 criteria providing a “level II” evidence of causality as well as fitting within the expected time course [2, 3].…”

“…Criteria have been published to evaluate potential causality for drugs implicated in DITP [3]. In our study patient, the medication fulfilled 3 of 4 criteria providing a “level II” evidence of causality as well as fitting within the expected time course [2, 3]. For the maximum level I strength of causality to be achieved, a rechallenge to suspected offending medication is required, which in most instances is impractical and unethical [3].…”

“…In our study patient, the medication fulfilled 3 of 4 criteria providing a “level II” evidence of causality as well as fitting within the expected time course [2, 3]. For the maximum level I strength of causality to be achieved, a rechallenge to suspected offending medication is required, which in most instances is impractical and unethical [3]. Many institutions advocate drug-specific antibody testing to confirm DITP diagnosis, which was not performed in this case.…”