Drug-induced thrombocytopenia in children

Reese, Jessica; Nguyen, Ly; Buchanan, George R.; Curtis, Brian R.; Terrell, Deirdra R.; Vesely, Sara K.; George, James N.

doi:10.1002/pbc.24682

Cited by 27 publications

(34 citation statements)

References 42 publications

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“…Secondary IT can be caused by the assumption of drugs and vaccines: drug-induced IT, ascribable in most of cases to the assumption of certain antibiotics, non-steroidal anti-inflammatory drugs, and antivirals, it is often not recognized, resulting in recurrent non-explained episodes of thrombocytopenia ( 21 ), that usually show a complete recovery after the withdrawal of the drug. Less commonly than in adulthood, it is possible to observe in childhood the development of heparin-induced thrombocytopenia ( 22 ).…”

Section: Etiology Of Itpmentioning

confidence: 99%

The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach

2017

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Primary immune thrombocytopenia (ITP) is the most common cause of thrombocytopenia in children and adolescents and can be considered as a paradigmatic model of autoimmune disease. This second part of our review describes the clinical presentation of ITP, the diagnostic approach and overviews the current therapeutic strategies. Interestingly, it suggests an algorithm useful for differential diagnosis, a crucial process to exclude secondary forms of immune thrombocytopenia (IT) and non-immune thrombocytopenia (non-IT), which require a different therapeutic management. Advances in understanding the pathogenesis led to new therapeutic targets, as thrombopoietin receptor agonists, whose role in treatment of ITP will be discussed in this work.

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Section: Etiology Of Itpmentioning

confidence: 99%

The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach

2017

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“…Immune thrombocytopenias are among the most important causes of acquired thrombocytopenias. Probable or definite drug-related thrombocytopenia can be induced by several drugs and may occur because of both decreased production and/or peripheral destruction of thrombocytes [1]. Polymyxins are effective antibiotics for resistant Gram-negative bacteria with a potential adverse effects of nephrotoxicity and neurotoxicity which are often dosedependent and reversible on discontinuation of treatment [2].…”

mentioning

confidence: 99%

“…In suspected drug-related thrombocytopenia other conditions that can cause thrombocytopenia must be excluded [1]. Drugrelated thrombocytopenia can be mediated by several drugs and may occur because of both decreased production and/or peripheral destruction of thrombocytes [1,3]. Immune thrombocytopenias are the most important reasons of acquired thrombocytopenias.…”

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confidence: 99%

Colistin-related thrombocytopenia

Küpeli

2015

Platelets

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“…The clinical presentation of both diseases might be similar, but the time course and resolution upon drug discontinuation can distinguish PIPT from DIPT. Drugs most associated with DIPT in children include acetaminophen, carbamazepine, ceftriaxone, phenytoin, quinine, sulfasalazine, and co‐trimoxazole …”

Section: Unpredictable Type B Reactionsmentioning

confidence: 99%

Adverse Drug Reactions in Children: The Double‐Edged Sword of Therapeutics

Elzagallaai

Greff

Rieder

2017

Clin Pharma and Therapeutics

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Adverse drug reactions (ADRs) represent a major health problem worldwide, with high morbidity and mortality rates. ADRs are classified into Type A (augmented) and Type B (bizarre) ADRs, with the former group being more common and the latter less common but often severe and clinically more problematic due to their unpredictable nature and occurrence at any dose. Pediatric populations are especially vulnerable to ADRs due to the lack of data for this age group from the drug development process and because of the wide use of off-label and unlicensed use of drugs. Children are more prone to specific types of ADRs because of the level of maturity of body systems involved in absorption, metabolism, transportation, and elimination of drugs. This state-of-the-art review provides an overview of definitions, classifications, epidemiology, and pathophysiology of ADRs and discusses the available evidence for related risk factors and causes of ADRs in the pediatric population.

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Drug-induced thrombocytopenia in children

Abstract: Drugs and other substances must be considered as potential causes of thrombocytopenia. Evidence from published reports and data for drug-dependent, platelet-reactive antibodies can help clinicians evaluate of children with unexpected thrombocytopenia.

Cited by 27 publications

References 42 publications

The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach

The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach

Colistin-related thrombocytopenia

Adverse Drug Reactions in Children: The Double‐Edged Sword of Therapeutics

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