Drug-induced urticaria

Tan, E.; Grattan, Clive

doi:10.1517/14740338.3.5.471

Cited by 41 publications

(18 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While angioedema is characterized by deep swelling in the submucosal or subcutaneous tissue, urticaria is associated with transient swelling of the skin . Drug‐induced urticaria can be immunologically mediated (eg with antibiotics), or nonimmunologically mediated (eg with NSAIDs) Our study also observed radiocontrast media, specifically iohexol, as a frequent causative agent for urticaria.…”

Section: Discussionsupporting

confidence: 52%

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

Wong

Tham

Goh

et al. 2019

Pharmacology Res & Perspec

View full text Add to dashboard Cite

We analyzed the spontaneous adverse event database in Singapore to determine the types of cutaneous adverse drug reactions ( CADR s) and causative drugs reported. We selected 10 CADR s‐of‐interest, and identified the suspected drugs and the characteristics of the at‐risk population. ADR reports received from 2006 to 2015 of the system organ class “Skin and Appendages Disorders” were analyzed based on patient demographics, the types of CADR s, suspected drugs, outcome, and latency period. Of the 104 372 reports analyzed, 56.2% involved females and 72.5% involved Chinese patients. The mean age was 41.1 years old. The top CADR s reported were rash (including nonspecified rash, follicular rash, maculopapular rash, and vesicular rash) (67.2%) and angioedema (13.9%). The drugs frequently associated with the CADR s‐of‐interest include nonsteroidal antiinflammatory drugs and antibiotics with angioedema, iohexol with urticaria, and antiepileptics and allopurinol with Stevens‐Johnson syndrome ( SJS )/toxic epidermal necrolysis ( TEN ). A subgroup analysis based on age, sex, and race on the 10 CADR s‐of‐interest showed the following trends in reporting: Alopecia (reported more in females), drug hypersensitivity syndrome (more in males), angioedema (more in younger patients), and photosensitivity (more in older patients). In general, the racial distribution across each CADR ‐of‐interest was consistent with that of Singapore's population, with slight deviations observed for SJS / TEN , photosensitivity and skin discoloration. We analyzed CADR reports from Singapore over 10 years, and identified the types of CADR s reported, and their associated drugs, latency periods and patient characteristics. Such information could add value to healthcare professionals as they assess CADR cases and evaluate suspected drugs.

show abstract

Section: Discussionsupporting

confidence: 52%

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

Wong

Tham

Goh

et al. 2019

Pharmacology Res & Perspec

View full text Add to dashboard Cite

show abstract

“…A few cases of angioedema have been described in patients treated with angiotensin (AT) II receptor antagonists with a history of ACEI-induced angioedema. Therefore, AT II receptor antagonists should be administered with caution to patients with previous ACEI-induced angioedema and only if no other alternatives can be used [114].…”

Section: Ace Inhibitor-induced Angioedemamentioning

confidence: 99%

Urticaria: current and future treatments

Borzova

Grattan

2007

Expert Review of Dermatology

View full text Add to dashboard Cite

Urticaria is a common disorder with diverse clinical presentations. Correct recognition of the different clinical patterns promotes more effective treatment. Management involves treatment of any identifiable external causes, including infection, avoidance of drug, food and physical triggers and the appropriate use of pharmacological therapies. These can be divided into first-, second-and third-line approaches. The choice of treatment will be influenced by many factors, including drug licensing, safety, pattern of disease, disease severity, pharmacoeconomic considerations and patient preference. H1 antihistamines are the mainstay of treatment of most patterns of urticaria and are effective in the majority of patients with mast cell-mediated disease. Second-generation antihistamines have a better therapeutic index and improved pharmacodynamic properties compared with older 'classic' antihistamines and should be prescribed preferentially for chronic urticaria. Patients who are unresponsive to H1 antihistamines at full dose may require short-term treatment with oral corticosteroids but their long-term use for urticaria should be avoided whenever possible on account of the risk of serious adverse effects. Antileukotrienes and alternative second-line agents, prescribed off licence, can be helpful for patients who respond poorly to antihistamines when taken in conjunction but a better evidence base is needed to guide prescribing. Third-line immunosuppressive therapies can be considered for debilitating urticaria, especially for patients with corticosteroid-dependent chronic disease, and may have some potential to modify the natural course of the illness. Possible new therapeutic approaches on the horizon include new H1 antihistamines, H4 receptor antagonists, a histidine decarboxylase inhibitor under development and biological agents that target histamine-releasing autoantibody production and function.

show abstract

“…En sık sorumlu tutulan ilaç grupları antibiyotikler, nonsteroid anti-inflamatuvar (NSAİ) ilaçlar, opioidler ve kas gevşeticileridir (2). İlaçlar farklı mekanizmalarla ürtiker ve anjiyoödeme neden olabilir.…”

Section: Introductionunclassified

Bir Kalsiyum Kanal Blokeri Olan Lerkanidipin Kullanımı Sonrası Akut Ürtiker ve Anjiyoödem

Ünal¹,

Demirtürk²

2017

Asthma Allergy Immunol

View full text Add to dashboard Cite

ÖZAnjiyotensin dönüştürücü enzim (ACE) inhibitörleri, anjiyotensin reseptör blokerleri (ARB), beta-blokerler ve kalsiyum kanal blokerleri gibi çeşitli antihipertansif ilaçlar, allerjik reaksiyona neden olabilir. Kalsiyum kanal blokerlerine bağlı ürtiker ve anjiyoödem ise olgu sunumları halinde nadiren bildirilmektedir. Bu bildiride bir kalsiyum kanal blokeri olan lerkanidipin kullanımını takiben akut ürtiker ve anjiyoödem gelişen ilk olguyu sunmaktayız. ABSTRACTAntihypertensive medications such us angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and calcium channel blockers may cause allergic reactions. Urticaria and angioedema due to calcium channel blockers have been rarely reported. To our knowledge, this is the first case report suggesting a possible link between urticaria and angioedema and lercanidipine, a calcium channel blocker.

show abstract

Drug-induced urticaria

Cited by 41 publications

References 72 publications

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

Urticaria: current and future treatments

Bir Kalsiyum Kanal Blokeri Olan Lerkanidipin Kullanımı Sonrası Akut Ürtiker ve Anjiyoödem

Contact Info

Product

Resources

About