Drug Interaction Between Oral Cyclosporine Modified and Iron

Abstract

Taking into account that joint administration of oral iron and cyclosporine modified can generate a physicochemical interaction that involves a decrease in the absorption of cyclosporine modified, we believe that it is necessary to recommend spacing administrations of both drugs as well as monitoring levels of cyclosporine in order to ensure optimal levels of immunosuppression.

Cyclosporine use in Hematopoietic Stem Cell Transplantation: Pharmacokinetic Approach

“…A physiochemical interaction has been proposed between CsA and cations, namely iron supplements, which will be important in designing administration time schedules [125].…”