Drug interaction of chemotherapy drugs and medicinal plants

Alves, Gabriela Quirino; Brito, Jenyffer Kyara Chaves; Silva, Iran Alves da; Queiroz, Ana Luiza Florencio Galvão de; Melo, Pedro Rafael de Almeida; Nascimento, Matheus Marques do; Coimbra, Cynthia Gisele de Oliveira

doi:10.15171/ijpni.2020.03

Int J Phytocos Nat Ingred

2020

DOI: 10.15171/ijpni.2020.03

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Drug interaction of chemotherapy drugs and medicinal plants

Gabriela Quirino Alves¹,

Jenyffer Kyara Chaves Brito²,

Iran Alves da Silva³

et al.

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2023

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“…This necessitates the search for new lead compounds for the remedies of various diseases (Ved et al, 2020). In recent times, there has been resurgence of interest in natural products as major source of medicines of novel molecules for use in the elucidation of physiological and biochemical principles (Alves, 2020;Freitas et al, 2021). It has been reported that plant based extracts use as remedies are safer, cheap and have less side effects than synthetic drugs (Morsy, 2019).…”

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Cytotoxic Correlation of Selected Nigerian Ethnomedicinal Plants Using Brine Shrimp Lethality Test

Muhammad,

Mann,

Fadipe

et al. 2023

jasem

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Cytotoxicity is the toxicity caused due to the action of chemotherapeutic agents on living cells and its mechanism lies in the ability of chemotherapeutic agents to oxidatively attack vital components inside cells, creating reactive free radicals that can cause adverse effects in the nucleus, proteins, and/or lipids. There are several ethnomedicinal plants in Nigeria used in the amelioration of several illnesses, however, information on their cytotoxic assessments are rare. Hence, the present study was to assess the cytotoxic correlation of selected Nigerian ethnomedicinal plants using brine shrimp lethality test. Data show that calculated LC50 of the extracts ranged from 83.71-265.90 μg/cm3, with K. africana having the highest anticancer activity with LC50 83.71 μg/cm3. The present result is an indicative of the presence of cytotoxic compounds that are attributable to the bioactive components with high phenolic contents derived from plant parts (fruit, leaf, seed) that accounted for the pharmacological effects or potential against various human diseases such as cancer. The cytotoxicity for the various plant parts’ extracts showed concentration dependent manner and it was determine candidate plants for isolation of cytotoxic principle.

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mentioning

confidence: 99%

Cytotoxic Correlation of Selected Nigerian Ethnomedicinal Plants Using Brine Shrimp Lethality Test

Muhammad,

Mann,

Fadipe

et al. 2023

jasem

View full text Add to dashboard Cite

show abstract

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Drug interaction of chemotherapy drugs and medicinal plants

Cited by 1 publication

References 0 publications

Cytotoxic Correlation of Selected Nigerian Ethnomedicinal Plants Using Brine Shrimp Lethality Test

Cytotoxic Correlation of Selected Nigerian Ethnomedicinal Plants Using Brine Shrimp Lethality Test

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