Drug interaction with radiopharmaceuticals: a review

Abstract

Clinical images are worthwhile in Health Sciences and their analysis and correct interpretation aid the professionals,such as physicians, physiotherapists and occupational therapists, to make decisions and take subsequent therapeutic and/or rehabilitation measures. Other factors, besides the state of the disease, may interfere and affect the bioavailability of the radiopharmaceuticals (radiobiocomplexes) and the quality of the SPECT and PET images. Furthermore, the labeling of some of these radiobiocomplexes, such as plasma proteins, white blood cells and red blood cells, with 99mT, can also be modified. These factors include drugs (synthetic and natural) and dietary conditions, as well as some medical procedures (invasive or non-invasive), such as radiation therapy, surgical procedures, prostheses, cardioversion, intubation, chemoperfusion, external massage, immunotherapy, blood transfusion and hemodialysis. In conclusion, the knowledge about these factors capable of interfering with the bioavailability of the radiobiocomplexes is worthwhile for secure diagnosis. Moreover, the development of biological models to study these phenomena is highly relevant and desirable.<br>Imagens clínicas são valiosas em Ciências da Saúde e a análise e a interpretação correta das mesmas auxiliam os profissionais, como médico, fisioterapeuta, terapeuta ocupacional, na tomada de decisões e subseqüentes ações terapêuticas e/ou de reabilitação. Além das doenças outros fatores podem interferir e afetar a biodisponibilidade dos radiofármacos (radiobiocomplexos) e a qualidade das imagens (SPECT e PET). Além disso, a marcação de alguns desses radiobiocomplexos com Tc-99m, como proteínas plasmáticas, leucócitos e hemácias, também pode ser modificada. Entre esses fatores, estão drogas (sintéticas e naturais) e condições alimentares, assim como alguns procedimentos médicos (invasivos e não invasivos), como a radioterapia, processos cirúrgicos, próteses, cardioversão, intubação, quimioperfusão, massagem externa, imunoterapia, transfusão sanguínea e hemodiálise. Em conclusão, o conhecimento sobre esses efeitos capazes de interferir na biodisponibilidade de radiobiocomplexos é altamente relevante para diagnósticos precisos. Além disso, o desenvolvimento de modelos biológicos para estudar esses fenômenos é de elevada importância e desejável

Aptamer-based therapeutics and their potential in radiopharmaceutical design

“…Equipped with these new tools, the implementation of simple steps for the formation of a new class of therapeutic agents was one step away. The idea of attaching radionucleotides to a biological molecule is not new (Bernardo-Filho et al, 2005). Long and detailed studies have been carried out in the past with some success with antibodies, peptides or antisense targeting.…”

Radiopharmaceuticals for imaging chronic lymphocytic inflammation

“…Typical characteristics for an ideal radiopharmaceutical have been defined by different authors (Rennen et al, 2001;BleekerRovers et al, 2004;Bernardo-Filho et al, 2005, Buscombe, 2006. Although, no radiopharmaceutical has been discovered till now that fulfils all the characteristics of an ideal one, each has its own advantages and disadvantages.…”

Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats

“…It has already reported that the biodistribution of radiopharmaceuticals used in diagnostic imaging in nuclear medicine is also altered by including plant origin drugs (Hesslewood & Leung, 1994;Britto et al, 1998;Gomes et al, 2001;Mattos et al, 1999). It has been described that extracts of medicinal plants could interfere with the biodistribution of 99m Tc sodium pertechnetate particularly (Rebello et al, 2007;Rebello et al, 2008;Bernardo-Filho et al, 2005;Moreno et al, 2007;Jankovic & Djokic, 2005;Valenca et al, 2005). In these studies, alterations on the uptake of radiopharmaceutical were observed.…”