Drug Interactions in Psychiatric Practice

Ragheb, Mohamed A.

doi:10.1159/000468482

Cited by 16 publications

(1 citation statement)

References 97 publications

(113 reference statements)

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“…Concomitant administration of TCAs with guanethidine, methyldopa, or clonidine can inhibit the mechanism of these antihypertensive agents and possibly result in loss of blood pressure control. ', 36 The absorption of levodopa is reduced and the effects of anticholinergic agents, anticoagulants, and CNS depressants are potentiated when coprescribed with TCAs. Finally, TCAs taken with directacting sympathomimetics such as norepinephrine and epinephrine could potentiate arrhythmias, hypertension, and tachycardia.…”

Section: Drug Interactionsmentioning

confidence: 99%

Rational Drug Use in the Treatment of Depression

Cohen

1997

Pharmacotherapy

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New drugs are being developed for the management of depression in response to the growing awareness of the prevalence and disability associated with the disorder and the need for agents with improved side effect profiles. All antidepressants are equally effective for treating uncomplicated unipolar depression without psychotic features. For patients with atypical depression with prominent anxiety, agitation, sleep loss, and irritability, monoamine oxidase inhibitors are the first choice. Data are accumulating supporting the efficacy of selective serotonin reuptake inhibitors (SSRIs) in these depressive subtypes. Factors to consider when choosing an antidepressant include spectrum of adverse effects, long‐term tolerability dosing schedule, clinically significant drug interactions, underlying medical conditions, earlier response to therapy, and pharmacoeconomics. Based on these criteria, it is suggested that a trial with the SSRIs be attempted first. Venlafaxine and nefazodone are newer agents with mechanisms of action that have advantages over tricyclic antidepressants and monoamine oxidase inhibitors. Choosing a drug that is effective, tolerable, and convenient will improve the likelihood of achieving and maintaining a full remission. It will also decrease the morbidity and mortality of this very treatable disease.

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Section: Drug Interactionsmentioning

confidence: 99%