Drug Interactions with Fluconazole

Kowalsky, Steven F.

doi:10.1002/j.1875-9114.1990.tb02605.x

Cited by 8 publications

(1 citation statement)

References 29 publications

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“…Fluconazole poses a risk precipitating drug interactions due to inhibition of CYP3A4, CYP2C9, and CYP2C19 enzymes. Many of the interactions were evaluated with low doses of fluconazole (50–100 mg), and the significance of using higher doses (400–800 mg/day) is not well defined [ 48 , 49 ]. There is risk of ventricular arrythmias in patients with inherited long QT syndrome or use in combination with other drugs that prolong the QTc [ 50 , 51 ].…”

Section: Effects On Antifungal Stewardship Practicementioning

confidence: 99%

Challenges Facing Antimicrobial Stewardship Programs in the Endemic Region for Coccidioidomycosis

Hayes,

Nix

2024

Open Forum Infectious Diseases

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Coccidioidomycosis poses a significant cost and morbidity burden in the United States. Additionally, coccidioidomycosis requires constant decision-making related to prevention, diagnosis, and management. Delays in diagnosis leads to significant consequences, including unnecessary diagnostic workup and antibacterial therapy. Antifungal stewardship considerations regarding empiric, prophylactic, and targeted management of coccidioidomycosis are also complex. In this review, the problems facing antimicrobial stewardship programs (ASPs) in the endemic region for coccidioidomycosis, consequences due to delayed or missed diagnoses of coccidioidomycosis on antibacterial prescribing, and excess antifungal prescribing for prevention and treatment of coccidioidomycosis are elucidated. Finally, our recommendations and research priorities for ASPs in the endemic region for coccidioidomycosis are outlined.

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Section: Effects On Antifungal Stewardship Practicementioning

confidence: 99%