Drug/ion co-delivery multi-functional nanocarrier to regenerate infected tissue defect

Lee, Jung Hwan; El‐Fiqi, Ahmed; Mandakhbayar, Nandin; Lee, Hae‐Hyoung; Kim, Hae‐Won

doi:10.1016/j.biomaterials.2017.07.014

Cited by 70 publications

(65 citation statements)

References 70 publications

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“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

Section: Resultsmentioning

confidence: 99%

“…Three studies agreed that Ag (2.1 wt%) had a toxic effect only when it was present with a high concentration (whose extract is undiluted or diluted 1:2) and that it retained its action even when the glasses were mixed (30:70, 50:50 glass:ECM wt ratio) with organic polymers. The remaining proved that 5 mol% of Ag are not toxic even if cells are directly exposed to the doped glass.…”

Section: Pure Bgsmentioning

confidence: 98%

“…Ag has been reported in seven selected articles. Four of them have examined the effect of adding Ag to sol–gel BGs on DPSCs. Three studies agreed that Ag (2.1 wt%) had a toxic effect only when it was present with a high concentration (whose extract is undiluted or diluted 1:2) and that it retained its action even when the glasses were mixed (30:70, 50:50 glass:ECM wt ratio) with organic polymers.…”

Section: Pure Bgsmentioning

confidence: 99%

“…Catauro et al showed that the bactericidal action of Ag‐doped glass against Staphylococcus aureus was concentration dependent. Lee et al studied the antibacterial effect of Ag‐doped glass on E. coli , E. faecalis , Streptococcus oralis , and S. mutans. They founded that the Ag‐free glass was unable to kill any of those bacteria and that the efficiency of the Ag‐doped glass was strain specific: using three different concentrations (40, 80, and 160 μg/mL) they found that E. coli and S. oralis were the most sensitive to the doping agent, whereas S. faecalis was sacrificed only when exposed to the highest concentration.…”

Section: Combined Materialsmentioning

confidence: 99%

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Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

et al. 2018

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Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement. The research ranged 5 years' window time (from January, 01, 2012, to August, 31, 2017) and the relevant studies were identified based on the inclusion/exclusion criteria. A total of 45 articles were selected from 244 initial returns, plus seven further articles coming from other sources were selected for the same purpose. From this systematic study, it is revealed that only 13 of the 52 articles have proved both the ability of BGs to differentiate dental cells at genetic level and their ability of triggering cell-mediated mineralization, but only six of them showed, along with cells, the antibacterial properties of the glasses. This review shows that sol-gel BGs are not toxic, can sustain cell proliferation and differentiation at a genetic level, and can keep the bacterial population under control. Moreover, a standard methodology and an ideal material are suggested. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018.

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“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

Section: Resultsmentioning

confidence: 99%

Section: Pure Bgsmentioning

confidence: 98%

Section: Pure Bgsmentioning

confidence: 99%

Section: Combined Materialsmentioning

confidence: 99%

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Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

et al. 2018

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“…Dental tissue engineering is an emerging field that considers dental pulp regeneration as a new solution for dental problems (7)(8)(9). A previous study examined the regeneration of dental pulp in vivo (10,11), indicating that dental pulp stem cells (DPSCs) had the potential for treating pulp disease.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells

Wang

Yuan

Sun

et al. 2020

Preprint

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This study aimed to observe the molecular mechanism underlying the effect of tumor necrosis factor-inducible protein 6 (TSG-6) on the bone morphogenetic protein-4 (BMP-4)/drosophila mothers against decapentaplegic protein(Smad) signaling pathway and mineralization of dental pulp stem cells (DPSCs) in inflammatory environment. Normal and TSG-6 gene-modified DPSCs were cultured in a mineralization-inducing fluid containing 0 and 50 ng/mL TNF-α separately. The real-time polymerase chain reaction was used to measure the expression of TSG-6 and odonto/osteogenic differentiation makers at the mRNA level. Western blot analysis and cellular immunofluorescence were used to observe the odonto/osteogenic differentiation of DPSCs and the variation of BMP-4/Smad signaling pathway at the protein level.Moreover, normal and modified DPSCs combined with hydrogel were used for subcutaneous implantation in nude mice. The expression of odonto/osteogenic markers and BMP-4/Smad-related proteins was lower in Ad-TSG-6 DPSCs than in normal DPSCs after mineralization induction, and was higher in TSG-6-RNAi DPSCs than in normal DPSCs after culturing with mineralization-inducing fluid containing 50 ng/mL TNF-α. The subcutaneous transplantation of normal and modified DPSCs combined with hydrogel in nude mice demonstrated that normal DPSCs were formed in the tissue containing collagen. The tissue formed by Ad-TSG-6 DPSCs was highly variable, and the cells were very dense. The expression of odonto/osteogenic markers of Ad-TSG-6 DPSCs were lower in Ad-TSG-6 DPSCs than in normal DPSCs. We can know that TNF-α regulates the expression of TSG-6, thereby inhibiting the BMP-4/Smad signaling pathway and the odonto/osteogenic differentiation ability of DPSCs.

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Bioactive Glasses as Carriers for the Controlled Release of Therapeutic Species

Zhu¹,

Zhu²

2022

Bioactive Glasses and Glass‐Ceramics

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Drug/ion co-delivery multi-functional nanocarrier to regenerate infected tissue defect

Cited by 70 publications

References 70 publications

Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells

Bioactive Glasses as Carriers for the Controlled Release of Therapeutic Species

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