Drug-loaded erythrocytes: Modern approaches for advanced drug delivery for clinical use

Berikkhanova, Kulzhan; Taigulov, Erlan; Bokebaev, Zhanybek; Kusainov, Aidar; Tanysheva, Gulyash; Yedrissov, Azamat; Seredin, German; Baltabayeva, Tolkyn; Zhumadilov, Zhaxybay

doi:10.1016/j.heliyon.2023.e23451

Heliyon

2024

DOI: 10.1016/j.heliyon.2023.e23451

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Drug-loaded erythrocytes: Modern approaches for advanced drug delivery for clinical use

Kulzhan Berikkhanova,

Erlan Taigulov,

Zhanybek Bokebaev

et al.

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2024

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Cited by 4 publications

References 119 publications

(217 reference statements)

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Harnessing cells to improve transport of nanomedicines

Bezze,

Mattioda,

Ciardelli

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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Harnessing cells to improve transport of nanomedicines

Bezze,

Mattioda,

Ciardelli

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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Recent advances with erythrocytes as therapeutics carriers

Hadi Barhaghtalab,

Tanimowo Aiyelabegan,

Maleki

et al. 2024

International Journal of Pharmaceutics

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Sodium-Selective Channelrhodopsins

Coli,

Gao,

Kaestner

2024

Cells

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Channelrhodopsins (ChRs) are light-gated ion channels originally discovered in algae and are commonly used in neuroscience for controlling the electrical activity of neurons with high precision. Initially-discovered ChRs were non-selective cation channels, allowing the flow of multiple ions, such as Na+, K+, H+, and Ca2+, leading to membrane depolarization and triggering action potentials in neurons. As the field of optogenetics has evolved, ChRs with more specific ion selectivity were discovered or engineered, offering more precise optogenetic manipulation. This review highlights the natural occurrence and engineered variants of sodium-selective channelrhodopsins (NaChRs), emphasizing their importance in optogenetic applications. These tools offer enhanced specificity in Na+ ion conduction, reducing unwanted effects from other ions, and generating strong depolarizing currents. Some of the NaChRs showed nearly no desensitization upon light illumination. These characteristics make them particularly useful for experiments requiring robust depolarization or direct Na+ ion manipulation. The review further discusses the molecular structure of these channels, recent advances in their development, and potential applications, including a proposed drug delivery system using NaChR-expressing red blood cells that could be triggered to release therapeutic agents upon light activation. This review concludes with a forward-looking perspective on expanding the use of NaChRs in both basic research and clinical settings.

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Drug-loaded erythrocytes: Modern approaches for advanced drug delivery for clinical use

Cited by 4 publications

References 119 publications

Harnessing cells to improve transport of nanomedicines

Harnessing cells to improve transport of nanomedicines

Recent advances with erythrocytes as therapeutics carriers

Sodium-Selective Channelrhodopsins

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