Drug-loaded implantable surgical cavity-adaptive hydrogels for prevention of local tumor recurrence

Zhuang, Bo; Cui, Ting; Xiao, Zhou; Jin, Yiguang

doi:10.1016/j.ijpharm.2020.119048

Cited by 46 publications

(26 citation statements)

References 40 publications

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“…The development of the in vivo cancer recurrence model is difficult and painful for the animals, wherein a layer of the tumor surrounding the skin is left voluntarily to construct the postoperative cancer recurrence model. Recently, many reports have shown the ability of the anticancer drug-loaded injectable hydrogel for the prevention of cancer recurrence in such small animal models. − Seib et al have used a transwell plate wherein the authors have reseeded the cancer cells in 2D to mimic the cancer relapse . However, no 3D in vitro model is available yet to study the same.…”

Section: Discussionmentioning

confidence: 99%

Drug Delivery of Anticancer Drugs from Injectable 3D Porous Silk Scaffold for Prevention of Gastric Cancer Growth and Recurrence

Gangrade

Mandal

2020

ACS Biomater. Sci. Eng.

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Localized cancer chemotherapy through injectable hydrogels is a next-generation advanced substitute for the currently operational systemic route of drug administration. Recently, several hydrogels have been developed for prospective drug delivery applications; however, no in vitro disease model is available to evaluate its long-term bioactivity in real time. In this regard, we have designed a porous silk scaffold that provides a single platform to accommodate both the soft hydrogel and cancer cells together. The stomach cancer (AGS) cells were seeded in the periphery of the silk scaffold, where they sit in the pores and form three-dimensional (3D) spheroids. Furthermore, the anticancer drug cisplatin-loaded nanocomposite injectable silk hydrogel was filled in the central cavity of the scaffold to evaluate its 11 day extended bioactivity. Such an arrangement keeps the released cisplatin in close contact with the spheroids for its sustained therapeutic effects. In an attempt to model cancer recurrence, the AGS cells were reseeded on the second day of treatment. Our data revealed that the shelf life and cytotoxic effects of cisplatin, which was explicitly releasing out from the nanocomposite silk hydrogel, were considerably enhanced. Hence, the reseeded AGS cells did not survive further on the scaffold, which also indicates its ability to inhibit cancer relapse. Conclusively, the current work showed a possible way to evaluate the long-term efficacy and bioactivity of the injectable hydrogel system in vitro for sustained drug delivery application.

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Section: Discussionmentioning

confidence: 99%

Drug Delivery of Anticancer Drugs from Injectable 3D Porous Silk Scaffold for Prevention of Gastric Cancer Growth and Recurrence

Gangrade

Mandal

2020

ACS Biomater. Sci. Eng.

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“…Hydrogels could be a good option for local drug delivery co-encapsulating photothermal agents and immune regulators in treatment of superficial tumors ( e.g., melanoma). And many studies applied the hydrogels on the surgical bed after tumor resection to eliminate the residual tumor cells 76 , 107 , 108 . The biocompatible hydrogels with high loading efficiency can achieve controlled or sustained release of immune modulators.…”

Section: Perspectivesmentioning

confidence: 99%

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

et al. 2021

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Cancer has been a great threat to humans for decades. Due to the limitations of monotherapy, combinational therapies such as photothermal therapy (PTT) and immunotherapy have gained increasing attention with expectation to overcome the shortfalls of each other and obtain satisfactory therapeutic outcomes. PTT can inhibit primary tumors by thermal ablation but usually fails to achieve complete eradication and cannot prevent metastasis and recurrence. Meanwhile, the efficacy of immunotherapy is usually attenuated by the weak immunogenicity of tumor and the immunosuppressive tumor microenvironment (ITM). Therefore, many recent studies have attempted to synergize PTT with immunotherapy in order to enhance the therapeutic efficacy. In this review, we aim to summarize the cutting-edge strategies in combining nano-based PTT with immunotherapy for cancer treatment. Herein, the combination strategies were mainly classified into four categories, including 1) nano-based PTT combined with antigens to induce host immune responses; 2) nano-based PTT in combination with immune adjuvants acting as in situ vaccines; 3) nano-based PTT synergized with immune checkpoint blockade or other regulators to relieve the ITM; 4) nano-based PTT combined with CAR-T therapy or cytokine therapy for tumor treatment. The characteristics of various photothermal agents and nanoplatforms as well as the immunological mechanisms for the synergism were also introduced in detail. Finally, we discussed the existing challenges and future prospects in combined PTT and immunotherapy.

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“…In situ gelling systems were also explored as platforms to deliver anti-cancer drugs to tumors as post-surgical implants as these are highly malleable and easy to use [25].…”

Section: In Situ Forming Laddsmentioning

confidence: 99%

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

Abdelkader

Fathalla

Seyfoddin

et al. 2021

Advanced Drug Delivery Reviews

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Drug-loaded implantable surgical cavity-adaptive hydrogels for prevention of local tumor recurrence

Cited by 46 publications

References 40 publications

Drug Delivery of Anticancer Drugs from Injectable 3D Porous Silk Scaffold for Prevention of Gastric Cancer Growth and Recurrence

Drug Delivery of Anticancer Drugs from Injectable 3D Porous Silk Scaffold for Prevention of Gastric Cancer Growth and Recurrence

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

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