Drug‐Loaded Mesoporous Tantalum Oxide Nanoparticles for Enhanced Synergetic Chemoradiotherapy with Reduced Systemic Toxicity

Chen, Yuyan; Song, Guosheng; Dong, Ziliang; Yi, Xuan; Chao, Yu; Liang, Chao; Yang, Kai; Cheng, Liang; Liu, Zhuang

doi:10.1002/smll.201602869

Cited by 69 publications

(49 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[200] Different from mesoporous silica which although is an ideal drug carrier, by itself has minimal radio-sensitization effect, hollow tantalum oxide nanoshells was developed by our recent work for enhanced chemo-radiotherapy. [81] Such mTa 2 O 5 loaded with DOX could offer a strong synergistic therapeutic effect during chemo-radiotherapy and showed remarkably reduced side effects compared to free DOX, which at the same dose during chemo-radiotherapy appeared to be lethal to animals. [80] Moreover, TaOx nanoshells could bind with Fe 3+ and radiolabelled with 99m Tc via a chelator-free manner for dual-modal MR and single photon emission computed tomography (SPECT) imaging.…”

Section: Inorganic Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

“…[78] As a high-Z element, Ta possesses a large X-ray attenuation coefficient comparable to that of gold. [79][80][81] Those TaOx nanomaterials possess large X-ray attenuation ability and thus could act as a radio-sensitizer to deposit more radiation energy into cancer cells to enhance RT via Compton scattering and Auger effect. [79][80][81] Those TaOx nanomaterials possess large X-ray attenuation ability and thus could act as a radio-sensitizer to deposit more radiation energy into cancer cells to enhance RT via Compton scattering and Auger effect.…”

Section: Other Types Of Nanostructures Containing High-z Elementsmentioning

confidence: 99%

“…[212,213] Abraxane is an albumin based nanoparticles containing paclitaxel (130 nm) and has been clinically approved for the treatment of metastatic Albumin nanoparticles Paclitaxel [189][190][191] Poly(lactic-co-glycolic acid) nanoparitlces (PLGA) Paclitaxel, Etanidazole, 5-Fluorouracil, or NU7441 [124,[192][193][194][195][196] Cyclodextrin Camptothecin [188] Au nanoparticles Cisplatin or Trastuzumab [197][198][199] Mesoporous silica nanoparticles Cisplatin, Selenocystine, or Topotecan [200][201][202] UCNP-silica nanorattles Cisplatin or Docetaxel [57,61] Hollow or mesoporous TaOx nanoparticles 7-ethyl-10-hydroxycamptothecin or Doxorubicin [80,81] Chemo-RIT Liposomes 111 In -vinorelbine, 188 Re -doxorubicin, or 99 Y -paclitaxel [203][204][205][206][207] Polydopamine nanoparticles 131 I -Doxorubicin [156] Thermosensitive micelles 131 I -Doxorubicin [208] Albumin nanoparticles 131 I -Paclitaxel [150] Core-shell Bi 2 S 3 @mesoporous silica 32 P -Doxorubicin [67] www.advmat.de www.advancedsciencenews.com breast cancer. [212,213] Abraxane is an albumin based nanoparticles containing paclitaxel (130 nm) and has been clinically approved for the treatment of metastatic Albumin nanoparticles Paclitaxel [189][190]…”

Section: Polymeric Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

See 2 more Smart Citations

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

Self Cite

View full text Add to dashboard Cite

Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

show abstract

Section: Inorganic Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

Section: Other Types Of Nanostructures Containing High-z Elementsmentioning

confidence: 99%

Section: Polymeric Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

See 1 more Smart Citation

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Up to now, various kinds of nanoparticles formulation of radiosensitive drugs for increasing the efficacy of RT have been designed . For example, based on the effective radiosensitization effect of chemodrug CDDP, Fan et al designed rattle‐structured multifunctional upconversion core/porous silica shell nanotheranostics (UCSNs) to deliver CDDP into tumor cells for achieving chemotherapy/RT synergetic treatment .…”

Section: General Strategies Of Nanomaterial‐mediated Tumor Radiosensimentioning

confidence: 99%

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

et al. 2018

View full text Add to dashboard Cite

Nano-radiosensitization has been a hot concept for the past ten years, and the nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated radiation enhancement. Recently, various new nanomaterial-mediated radiosensitive approaches have been successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming intracellular reduced glutathione (GSH), overcoming tumor hypoxia, and various synergistic radiotherapy ways. These strategies may open a new avenue for enhancing the radiotherapeutic effect and avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods and their radiosensitive mechanisms are still rare. Therefore, the general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods. The strategies are divided into three general parts. First, methods on account of the intrinsic radiosensitive properties of nanoradiosensitizers for radiosensitization are highlighted. Then, newly developed synergistic strategies based on multifunctional nanomaterials for enhancing radiotherapy efficacy are emphasized. Third, nanomaterial-mediated radioprotection approaches for increasing the radiotherapeutic ratio are discussed. Importantly, the clinical translation of nanomaterial-mediated tumor radiosensitization is also covered. Finally, further challenges and outlooks in this field are discussed.

show abstract

“…and later their full potential in chemo‐radiotherapy was explored by Chen et al. In this later work, mesoporous Ta 2 O 5 nanocarriers were prepared to encapsulate and deliver DOX in synergistic chemo‐radiotherapy . The Ta 2 O 5 ‐PEG/DOX nanocarriers exhibited an improved therapeutic efficacy under X‐ray irradiation, and also possessed lower toxicity compared to free DOX.…”

Section: Enhancing the Effect Of Ionizing Radiationmentioning

confidence: 99%

Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers

Denkova

Liu

Men

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

Next to surgery, radiotherapy and chemotherapy are the two most commonly applied treatments against cancer. These therapies are often combined, but the therapeutic outcome is still limited. Nanocarriers may be the solution to many of the issues encountered when combining these therapies. In this review, the role of nanocarriers in combined radiotherapy and chemical cancer treatment is discussed, divided into four distinct strategy classes. For each strategy, examples of the literature are given to come eventually to conclusion on the possible translation to the clinic.

show abstract

Drug‐Loaded Mesoporous Tantalum Oxide Nanoparticles for Enhanced Synergetic Chemoradiotherapy with Reduced Systemic Toxicity

Cited by 69 publications

References 49 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers

Contact Info

Product

Resources

About