Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization

Banga, Resham J.; Krovi, Sai Archana; Narayan, Suguna P.; Sprangers, Anthony J.; Liu, Guoliang; Mirkin, Chad A.; Nguyen, SonBinh T.

doi:10.1021/acs.biomac.6b01563

Cited by 50 publications

(45 citation statements)

References 42 publications

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“…[8] However,N ab technology relies on specific hydrophobic interaction between albumin and drug molecules,limiting the type of chemotherapeutics that can be delivered. [10] However, previously reported DNA-based DDSs still lack the control in precisely tuning the number and type of loaded drug molecules. [9] Thus far, by non-covalently or covalently loading chemotherapeutics onto DNAn anostructures,avariety of DNA-based DDSs have been constructed to deliver chemodrugs either in vitro or in vivo.…”

mentioning

confidence: 99%

“…[9] Thus far, by non-covalently or covalently loading chemotherapeutics onto DNAn anostructures,avariety of DNA-based DDSs have been constructed to deliver chemodrugs either in vitro or in vivo. [10] However, previously reported DNA-based DDSs still lack the control in precisely tuning the number and type of loaded drug molecules. [11] Recently,w ep roposed as trategy that integrated nucleoside analogues (NAs) into DNAstrands and then assembled them into well-defined DNAn anostructures to construct precise nanomedicine.…”

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confidence: 99%

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A Camptothecin‐Grafted DNA Tetrahedron as a Precise Nanomedicine to Inhibit Tumor Growth

et al. 2019

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Most chemotherapeutics are hydrophobic molecules and need to be converted into hydrophilic form before administration. Based on the excellent hydrophilicity and programmability of DNA, now,ageneral strategy to construct ap recise drug-containing DNAf ramework for cancer treatment is reported. In this novel drug delivery system, carbonethyl bromide-modified camptothecin (CPT) is employed to directly react with phosphorothioate (PS) modified DNAs, resulting in the formation of chemotherapeutics-grafted DNAs with aresponsive disulfide linkage.Bytuning the number and site of PS modifications on DNAstrands,hydrophilicity of the obtained DNA-drug conjugates (DDCs) can be regulated to retain their aqueous solubility and capability of molecular recognition. Subsequently,p rogrammable DNAn anotechnology enables the self-assembly of ap recise drug-containing tetrahedral framework with stimuli-responsive feature and enhanced antitumor efficacy both in vitro and in vivo.

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confidence: 99%

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A Camptothecin‐Grafted DNA Tetrahedron as a Precise Nanomedicine to Inhibit Tumor Growth

et al. 2019

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“…7a). The doxorubicin-loaded SNAs were stable in biological media, could penetrate SKOV3 cancer cells, and were more cytotoxic against these cells than free doxorubicin [73]. …”

Section: Therapeutic Application Of Snasmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Spherical Nucleic Acid Nanoparticles: Therapeutic Potential

2018

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Spherical nucleic acids (SNAs) are highly oriented, well organized, polyvalent structures of nucleic acids conjugated to hollow or solid core nanoparticles. Because they can transfect many tissue and cell types without toxicity, induce minimum immune response, and penetrate various biological barriers (such as the skin, blood-brain barrier, and blood-tumor barrier), they have become versatile tools for the delivery of nucleic acids, drugs, and proteins for various therapeutic purposes. This article describes the unique structures and properties of SNAs and discusses how these properties enable their application in gene regulation, immunomodulation, and drug and protein delivery. It also summarizes current efforts towards clinical translation of SNAs and provides an expert opinion on remaining challenges to be addressed in the path forward to the clinic.

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“…Crosslinkers that degrade or hydrolyze in response to different endogenous stimuli such as acidic pH (e.g. 2,2-dimethacroyloxy-1-ethoxypropane [24,74], HEMA-lactate-Dextran [75–78], poly(l-lactic acid)[79]), redox potential (e.g. bis(2-methacryloyloxyethyl) disulfide [80] and disulfide-containing crosslinker N,N’- bis(acryloyl) cystamine [40]) or enzymes (e.g.…”

Section: Thermoresponsive Nanomaterialsmentioning

confidence: 99%

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Sahle

Gulfam

Lowe

2018

Drug Discovery Today

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Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical stimuli-responsive nanotherapeutics.

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Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization

Cited by 50 publications

References 42 publications

A Camptothecin‐Grafted DNA Tetrahedron as a Precise Nanomedicine to Inhibit Tumor Growth

A Camptothecin‐Grafted DNA Tetrahedron as a Precise Nanomedicine to Inhibit Tumor Growth

Spherical Nucleic Acid Nanoparticles: Therapeutic Potential

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

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