Drug‐Loaded Superparamagnetic Iron Oxide Nanoparticles for Combined Cancer Imaging and Therapy In Vivo

Abstract

Multitasking rust ball: The questions of where a tumor is located, whether drugs are properly delivered to the tumor, and what the therapeutic response of the tumor is, could be answered by using simple but smart, drug‐loaded superparamagnetic iron oxide nanoparticles that can accumulate in tumor with high efficiency thanks to the presence of rationally engineered polymer coating layers.

Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles

“…Following their results, accumulation of SPIONs in gliosarcomas can be significantly enhanced by magnetic targeting and successfully quantified by MR imaging with no toxicity observation. Yu et al 137 reported that the excellent passive tumor targeting efficiency of thermally cross-linked (TCL)-SPIONs allowed detection of tumors by MR imaging and at the same time delivery of sufficient amounts of anticancer drugs that in turn were released from the nanoparticles to exhibit anticancer activity. Consequently, doxorubicin@TCL-SPIONs showed exceptional antitumor effects without any systemic toxicity.…”

Nonmonotonic evolution of the blocking temperature in dispersions of superparamagnetic nanoparticles

“…Envisaging new methods for the synthesis of monodisperse magnetic nanoparticles (NPs) constitutes one of the most active and challenging research fields in materials science due to the almost infinite uses foreseen for these systems in biomedicine, 1 magnetic recording, 2 energy production, etc. 3 Many of these applications rely on the possibility of obtaining well dispersed assemblies of NPs in a non-magnetic matrix (normally diamagnetic solids like polymers, SiO 2 , etc).…”

Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields

“…Nanoparticles of iron oxide possess superparamagnetic properties, whereby magnetism is 69 only present when under direct energy from an external magnetic field [9]. Other advantages of iron 70 oxide include its ability to be used in magnetic resonance imaging and induce cytotoxicity through near 71 infrared induced hyperthermia [10]. Unfortunately, iron oxide alone in physiological media is unstable, 72 resulting in oxidation, aggregation and precipitation [10][11][12][13].…”