Drug lymphocyte stimulation test is not useful for side effects of anti-tuberculosis drugs despite its timing

Miwa, Seiichi; Suzuki, Yuzo; Shirai, Masahiro; Ohba, Hisano; Kanai, Masashi; Eifuku, Tatsuru; Suda, Takafumi; Hayakawa, H; Chida, Keiji

doi:10.5588/ijtld.11.0163

Cited by 3 publications

(1 citation statement)

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“…However, the validity of DLST for testing anti-TB drugs remains controversial, and only two previously reported patients with RFP-induced pneumonitis were positive for DLST (6,8). In fact, the sensitivity of DLST for RFP has been reported to be only 13.6% (11), while another report concluded that DLST is not useful for diagnosing drug-induced pneumonitis (12).…”

Section: Discussionmentioning

confidence: 94%

Pneumonitis Induced by Rifampicin: A Case Report and Literature Review

et al. 2013

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An 84-year-old woman being treated for miliary tuberculosis (TB) with rifampicin (RFP), isoniazid (INH), ethambutol (EB) and corticosteroids suffered from a persistent fever for five months. While tapering the dose of prednisolone, chest computed tomography (CT) revealed diffuse ground glass opacities (GGO) and bronchoalveolar lavage fluid (BALF) showed an increase in lymphocytes. After the anti-TB drugs were discontinued and the dose of the corticosteroids was increased, the CT findings and fever improved considerably. However, readministration of RFP provoked an inflammatory reaction, leading to a diagnosis of RFP-induced pneumonitis. This condition is very rare. This is the first report of RFP-induced pneumonitis occurring during adjunct steroid therapy.

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Section: Discussionmentioning

confidence: 94%