Drug management in emergent liver transplantation of mitochondrial disorder carriers: review of the literature

Abstract

There are no randomized, controlled, trial-based indications regarding safe anesthetic drugs to be used perioperatively in MRCD carriers. Consultation among geneticists, anesthesiologists, intensivists, and surgeons is essential in patients with known/suspected metabolic syndrome for planning appropriate perioperative care.

Liver transplantation for pediatric inherited metabolic disorders: Considerations for indications, complications, and perioperative management

“…Because of a wide variety of symptoms and severity in mitochondrial disorders, selection of medications requires considerable attention for each patient. Drug management for LT anesthesia in mitochondrial disorders is well discussed in a review by Vater et al .…”

Kidney Transplantation in a Patient with MELAS: A Case Report and Review of the Literature on Medication Use

“…However, the researchers concluded that patients with mitochondrial disease should not be excluded from transplantation [12]. Finally, an article published by Vater and colleagues reviewed existing literature on transplantation patients with mitochondrial disorders and reported a case of an emergent liver transplant [13]. The article discussed both the paucity of literature on perioperative management of transplant recipients with mitochondrial disorders as well as the conflicting nature of reports with safety of anesthesia and perioperative drugs.…”