Drug Metabolism and Pharmacogenetics

Chan, June M.

doi:10.1016/b978-0-323-48110-6.00004-1

Cited by 9 publications

(2 citation statements)

References 100 publications

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“…Seven metabolites in the spleen and lungs and six in thyroids were detected (Table 3), all with a C max at 2 h after ROO ingestion. The activity of metabolizing enzymes in the endothelial cells of lungs [43,44] and their expression in macrophages and lymphocytes in the white pulp region of the spleen [20] could explain the presence of these metabolites in these tissues.…”

Section: Spleen Lungs and Thyroidsmentioning

confidence: 99%

LC-ESI-LTQ-Orbitrap-MS for Profiling the Distribution of Oleacein and Its Metabolites in Rat Tissues

et al. 2021

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The purpose of this work was to study the distribution of oleacein (OLEA) and its metabolites in rat plasma and different tissues, namely brain, heart, kidney, liver, lung, small intestine, spleen, stomach, skin, and thyroid, following the acute intake of a refined olive oil containing 0.3 mg/mL of OLEA. For this purpose, a distribution kinetics study was carried out. The plasma and tissues were collected at 1, 2, and 4.5 h after the intervention, and analyzed by LC-ESI-LTQ-Orbitrap-MS. Unmetabolized OLEA was detected in the stomach, small intestine, liver, plasma and, most notably, the heart. This finding may be useful for the development of new applications of OLEA for cardiovascular disease prevention. Noteworthy are also the high levels of hydroxytyrosol (OH-TY) and OLEA + CH3 found in the small intestine, liver, and plasma, and the detection of nine OLEA metabolites, five of them arising from conjugation reactions. Liver, heart, spleen, and lungs were the target tissues where the metabolites were most distributed. However, it is important to note that OH-TY, in our experimental conditions, was not detected in any target tissue (heart, spleen, thyroids, lungs, brain, and skin). These results shed further light on the metabolism and tissue distribution of OLEA and contribute to understanding the mechanisms underlying its effect in human health.

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Section: Spleen Lungs and Thyroidsmentioning

confidence: 99%

LC-ESI-LTQ-Orbitrap-MS for Profiling the Distribution of Oleacein and Its Metabolites in Rat Tissues

et al. 2021

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“…Biotransformation is the chemical alteration of a foreign molecule in the body (Chan 1959) to facilitate its elimination, and is fundamental to the understanding and evaluation of the health benefits associated with phenolic compounds (S Cicerale, Lucas, and Keast 2012).…”

Section: Metabolismmentioning

confidence: 99%

Health-promoting properties of oleocanthal and oleacein: Two secoiridoids from extra-virgin olive oil

Lozano‐Castellón

López‐Yerena

Alvarenga

et al. 2019

Critical Reviews in Food Science and Nutrition

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Extra virgin olive oil (EVOO) polyphenols, including the secoiridoids oleocanthal (OLC) and oleacein (OLE), are attracting attention because of their beneficial effects on health. Data on OLC and OLE bioavailability are scarce, as most research on EVOO polyphenols has concentrated on hydroxytyrosol, tyrosol, and oleuropein. Consequently, relevant goals for future research are the elucidation of OLC and OLE bioavailability and finding evidence for their beneficial effects through pre-clinical and clinical studies. The aim of this review is to shed light on OLC and OLE, focusing on their precursors in the olive fruit and the impact of agronomic and processing factors on their presence in EVOO. Also discussed are their bioavailability and absorption, and finally, their bioactivity and health-promoting properties.

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Acyl Group Migration in Pyranosides as Studied by Experimental and Computational Methods

Lassfolk

Pedrón

Tejero

et al. 2022

Chemistry A European J

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Acyl group migration affects the synthesis, isolation, manipulation and purification of all acylated organic compounds containing free hydroxyl groups, in particular carbohydrates. While several isolated studies on the migration phenomenon in different buffers have been reported, comprehensive insights into the overall migration process in different monosaccharides under similar conditions have been lacking. Here, we have studied the acyl migration in different monosaccharides using five different acyl groups by a combination of experimental, kinetic and theoretical tools.The results show that the anomeric configuration in the monosaccharide has a major influence on the migration rate, together with the relative configurations of the other hydroxyl groups and the nature of the migrating acyl group. Full mechanistic model, based on computations, demonstrates that the acyl migration proceeds through an anionic stepwise mechanism with linear dependence on the [OH À ] and the pK a of the hydroxyl group toward which the acyl group is migrating.

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Drug Metabolism and Pharmacogenetics

Cited by 9 publications

References 100 publications

LC-ESI-LTQ-Orbitrap-MS for Profiling the Distribution of Oleacein and Its Metabolites in Rat Tissues

LC-ESI-LTQ-Orbitrap-MS for Profiling the Distribution of Oleacein and Its Metabolites in Rat Tissues

Health-promoting properties of oleocanthal and oleacein: Two secoiridoids from extra-virgin olive oil

Acyl Group Migration in Pyranosides as Studied by Experimental and Computational Methods

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