Drug Mixtures and Ethanol as Compound Internal Stimuli

Stolerman, I. P.; Mariathasan, E. A.; White, John A.; Olufsen, K. S.

doi:10.1016/s0091-3057(99)00087-8

Cited by 30 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This interpretation seems unlikely for a number of reasons. First, in a similar study, B6 and D2 mice showed no difference in learning a nicotine discrimination (Stolerman et al, 1999). Second, a number of studies have Fig.…”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Discriminative Stimulus Effects of Ethanol in C57BL/6J and DBA/2J Inbred Mice

Shelton

Grant

2002

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

The initial stimulus effects of 1.5 g/kg ethanol may be more salient in D2 than B6 mice. This does not appear to result from differences in the neurotransmitter systems that mediate ethanol's discriminative stimulus effects. In both strains, gamma-aminobutyric acid-positive modulators and a noncompetitive NMDA antagonist substituted for ethanol. However, strain differences did exist in the potency of gamma-aminobutyric acid-positive modulators and morphine for suppressing operant responding.

show abstract

Section: Discussionmentioning

confidence: 82%

“…However, the discriminative stimulus effects of nicotine have been compared in B6 and D2 mice (Stolerman et al, 1999). In that study, both B6 and D2 mice successfully learned a 0.8 mg/kg nicotine discrimination, and B6 and D2 mice had similar profiles for the ability of lower doses of nicotine to substitute for the 0.8 mg/kg nicotine training dose.…”

mentioning

confidence: 99%

Discriminative Stimulus Effects of Ethanol in C57BL/6J and DBA/2J Inbred Mice

Shelton

Grant

2002

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…Nicotine as an interoceptive stimulus is presumably a complex polymodal event with its elements reflecting the neurobiological processes on which the drug acts directly or indirectly (Balster, 1988;Stolerman et al, 1999;Bevins and Murray, 2011). Because receptor specificity can vary with drug dose, the interoceptive stimulus effects of a low dose of a drug can differ from a higher dose in its general intensity, its neurobiological elements, and in the salience of those particular stimulus elements (Bevins and Murray, 2011).…”

Section: Discussionmentioning

confidence: 99%

Interoceptive conditioning with the nicotine stimulus

Polewan

Savala

Bevins

2013

Behavioural Pharmacology

View full text Add to dashboard Cite

Interoceptive conditioning involving the nicotine stimulus likely contributes to chronic tobacco use. To better understand the nature of this interoceptive conditioning, we compared generalization during repeated extinction with generalization in a 'transfer of extinction' test using a wide range of test doses. Rats were first trained in the discriminated goal-tracking task in which nicotine (0.2 or 0.4 mg/kg), but not saline, was paired with repeated intermittent access to sucrose. Across sessions, nicotine acquired control of approach behavior directed at the location of previous sucrose deliveries. Extinction followed with eight 20-min sessions without sucrose access; extinction doses of nicotine ranged from 0.05 to 0.6 mg/kg. In rats trained with 0.4 mg/kg, the 0.1, 0.2, and 0.6 mg/kg doses evoked comparable responding across extinction sessions; substitution was only partial at 0.05 and 0.075 mg/kg (i.e. above saline controls, but less than the training dose). With the 0.2 mg/kg training dose, complete generalization was seen only at the 0.1 and 0.4 mg/kg doses. After extinction, rats were given a transfer test with their training dose. Rats trained with 0.4 mg/kg showed full transfer of extinction learning with 0.1, 0.2, and 0.6 mg/kg (i.e. responding comparable with extinction with the training dose). Partial transfer was observed at 0.075 mg/kg. With the 0.2 mg/kg nicotine dose, only 0.4 mg/kg fully generalized; 0.075, 0.1, and 0.6 mg/kg showed partial transfer. Extinction with 0.05 mg/kg dose did not show transfer to either training dose. These findings indicated that conclusions regarding stimulus similarity across nicotine doses can vary with testing protocol.

show abstract

“…Additionally, ethanol has antagonist activity at the NMDA glutamate receptor, which appears selective for noncompetitive antagonism. Lastly, ethanol has activity at several 5-HT receptor systems, but agonism at the 5-HT 1B/2C receptor subtypes is most prominent [4, 6, 18]. …”

Section: Introductionmentioning

confidence: 99%

Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol

Allen

Ford

Grant

2017

Current Topics in Behavioral Neurosciences

View full text Add to dashboard Cite

The progress on understanding the pharmacological basis of ethanol’s discriminative stimulus effects has been substantial, but appears to have plateaued in the past decade. Further, the cross-species translational efforts are clear in laboratory animals, but have been minimal in human subject studies. Research findings clearly demonstrate that ethanol produces a compound stimulus with primary activity through GABA and glutamate receptor systems, particularly ionotropic receptors, with additional contribution from serotonergic mechanisms. Further progress should capitalize on chemogenetic and optogenetic techniques in laboratory animals to identify the neural circuitry involved in mediating the discriminative stimulus effects of ethanol. These infrahuman studies can be guided by in vivo imaging of human brain circuitry mediating ethanol’s subjective effects. Ultimately, identifying receptors systems, as well as where they are located within brain circuitry, will transform the use of drug discrimination procedures to help identify possible treatment or prevention strategies for alcohol use disorder.

show abstract

Drug Mixtures and Ethanol as Compound Internal Stimuli

Cited by 30 publications

References 28 publications

Discriminative Stimulus Effects of Ethanol in C57BL/6J and DBA/2J Inbred Mice

Discriminative Stimulus Effects of Ethanol in C57BL/6J and DBA/2J Inbred Mice

Interoceptive conditioning with the nicotine stimulus

Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol

Contact Info

Product

Resources

About