Drug modification of silver-induced sodium transport across toad skin

Gerencser, George A.; Loo, Stanley Y.; Cornette, Kuuleialoha M.

doi:10.1007/bf01953675

Cited by 7 publications

(3 citation statements)

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“…The previous findings by Gerencser et al (6,12,13) and the present observation ( Table 11) that Ag+ addition to the bathing medium, or Ag-AgC1 immersion electrodes, stimulates SCC that is identical to the active Na+ absorptive flux across the toad skin indicates that the Ag+-induced effects are Na+ specific. The effects observed by Ag+ addition are probably caused by Ag' C1-complexes, rather than the Ag+, as suggested by Gerencser et al (6).…”

Section: Methodssupporting

confidence: 56%

“…The effects observed by Ag+ addition are probably caused by Ag' C1-complexes, rather than the Ag+, as suggested by Gerencser et al (6). Previous observations also demonstrated that Ag+ addition had no effect on JIo of Na+, therefore eliminating any paracellular effects of this ion on Na+ transport (6,12). The finding that there was no significant change in the Ag+ or p-CMB-induced SCC by ethanol addition ( Fig.…”

Section: Methodsmentioning

confidence: 61%

“…These conclusions concur with those of Boyett and Van Bruggen (5) and Curran (4) who speculated that ethanol and Ag+, respectively, had effects on cellular ionic permeability in frog skin. Gerencser et al (6,12,13) suggested that Ag' or Ag+Cl-complexes and pCMB induced their effects on toad skin by interacting with sulfhydryl groups of the cells that permit active transport of Na' which was in concert with the conclusions of Curran (4) and Benos et al (14) in frog skin. Since ethanol had no effect on Na+ transport in the presence of Ag+ or p-CMB, it is not unreasonable to speculate that all three chemical species affect the same sulfhydryl ligand, Ag+ or Ag+Cl-complexes and p-CMB binding to it directly, whereas ethanol perturbing it indirectly by its effects on surrounding membrane phospholipids as postulated by Gutknecht and Tosteson ( 15).…”

Section: Methodsmentioning

confidence: 91%

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Interactive Effects of Ethanol and Silver on Sodium Transport across Toad Skin

Gerencser

Loo

Cornette

1984

Experimental Biology and Medicine

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Both ethanol and silver ions have been shown to affect ion transport across various epithelia. This investigation was principally undertaken to further define mechanisms of silver ions and ethanol, and their possible interactions, on sodium transport across toad skin. Isolated toad skin, mounted between identical oxygenated amphibian bicarbonate Ringer solutions, maintained stable transepithelial potential differences (serosa positive) and short-circuit currents for several hours at 25°C. It was observed that (1) ethanol inhibited the active transcellular component of sodium absorption and this effect was reversible; (2) inhibition of sodium transport by ethanol was directly proportional to the applied concentration; (3) pretreatment with silver ions prevented any ethanol effects; and (4) pretreatment with ethanol prevented any silver ion effects. It was concluded from these results that ethanol induced its inhibitory effects on membrane phospholipids thereby perturbing the function of a sulfhydryl ligand, while silver ion or silver chloride complex binding to this ligand would maintain its function in sodium transport despite the presence of ethanol.257

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Section: Methodssupporting

confidence: 56%

Section: Methodsmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 91%

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Interactive Effects of Ethanol and Silver on Sodium Transport across Toad Skin

Gerencser

Loo

Cornette

1984

Experimental Biology and Medicine

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Sublethal effects of neuroactive compounds on pheromone response thresholds in male oriental fruit moths

Linn

Roelofs

1984

Arch Insect Biochem Physiol

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The pheromone-mediated flight behavior of male Oriental fruit moths in a sustained-flight tunnel was observed after males were treated topically with sublethal concentrations of permethrin, carbaryl, chlordimeform, dieldrin, octopamine, serotonin, yohimbine, and cyproheptadine. With the exception of serotonin all compounds were found to disrupt one or more specific elements of the male precopulatory flight sequence. Among the insecticides, dieldrin was least active, whereas permethrin, carbaryl, and chlordimeform induced unique effects at specific phases of the sequence. Octopamine induced a hypersensitivity to the olfactory signal and mimicked one of the effects observed with chlordimeform. Yohimbine and cyproheptadine significantly decreased moth activation to the chemical signal but did not alter flight performance in responding moths. Yohimbine and cyproheptadine also reversed the effects induced by octopamine. The results of our study show that the complex precopulatory sequence of behaviors exhibited by males is very sensitive to sublethal concentrations of a range of neuroactive compounds.

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