2014
DOI: 10.1310/hpj4911-1009
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Drug Monographs: Belinostat and Idelalisib

Abstract: The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, … Show more

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Cited by 3 publications
(3 citation statements)
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“…In humans, after a single 30-minute intravenous infusion of BEL at the recommended dosage of 1000 mg/m 2 (Food and Drug Administration, 2014;Poole, 2014), the C max of BEL could reach to ∼128 6 44 mM (Yeo et al, 2012;Piper et al, 2014;Calvo et al, 2016). The time to plasma C max can be reached in about 30 minutes after the start of infusion (Yeo et al, 2012;Piper et al, 2014;Calvo et al, 2016). BEL is rapidly metabolized, with a plasma half-life (t 1/2 ) of 2-4 hours (Yeo et al, 2012;Piper et al, 2014;Bailey et al, 2016;Calvo et al, 2016).…”
Section: Resultsmentioning
confidence: 99%
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“…In humans, after a single 30-minute intravenous infusion of BEL at the recommended dosage of 1000 mg/m 2 (Food and Drug Administration, 2014;Poole, 2014), the C max of BEL could reach to ∼128 6 44 mM (Yeo et al, 2012;Piper et al, 2014;Calvo et al, 2016). The time to plasma C max can be reached in about 30 minutes after the start of infusion (Yeo et al, 2012;Piper et al, 2014;Calvo et al, 2016). BEL is rapidly metabolized, with a plasma half-life (t 1/2 ) of 2-4 hours (Yeo et al, 2012;Piper et al, 2014;Bailey et al, 2016;Calvo et al, 2016).…”
Section: Resultsmentioning
confidence: 99%
“…The time to plasma C max can be reached in about 30 minutes after the start of infusion (Yeo et al, 2012;Piper et al, 2014;Calvo et al, 2016). BEL is rapidly metabolized, with a plasma half-life (t 1/2 ) of 2-4 hours (Yeo et al, 2012;Piper et al, 2014;Bailey et al, 2016;Calvo et al, 2016). The plasma pharmacokinetic parameters from the previous studies in humans are presented in Table 2.…”
Section: Resultsmentioning
confidence: 99%
“…Table 3 summarizes the test concentration and clinical plasma exposure to test compounds. [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] Most of the skin toxic compounds decreased epidermal thickness by more than 20% at concentrations greater than 5-fold of clinical exposure (maximal free concentrations measured in plasma, Cmax_free). In contrast, most of the non-toxic compounds decreased epidermal thickness by less than 20% even at relatively high concentrations (5-fold higher than Cmax_free).…”
Section: Normalized Epidermal Thickness Enabled Cross-study Compariso...mentioning
confidence: 99%