Drug nanodelivery systems based on natural polysaccharides against different diseases

Rehman, Abdur; Jafari, Seid Mahdi; Tong, Qunyi; Riaz, Tahreem; Assadpour, Elham; Aadil, Rana Muhammad; Niazi, Sobia; Khan, Imran Mahmood; Shehzad, Qayyum; Ali, Ahmad; Khan, Sohail

doi:10.1016/j.cis.2020.102251

Cited by 97 publications

(46 citation statements)

References 171 publications

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“…Electrospinning has been extensively acknowledged in recent years, due to its ability to rapidly fabricate nanofibers and nanoparticles for drug and therapeutic agent delivery, tissue engineering and regenerative medicine, wound dressing, biological sensing and filtration devices applications [95,96]. Electrospinning is a top-down technique for the synthesis of 1D nanomaterials using a wide range of feedstock such as sol-gel, polymer, melts, or suspensions.…”

Section: Spinningmentioning

confidence: 99%

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Zare

Ramakrishna

2020

Proceedings of the 1st International Electronic Conference on Pharmaceutics

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Electrospinning is a powerful and cost-effective method that applies a strong electric field and polymer solution to fabricate versatile nanofiber using a wide array of raw materials for different biological applications. Electrospun nanofibers have developed as potential materials for the manufacturing of nanocarriers for therapeutic platforms due to controllable surface decoration, large surface areas, complex pore structure, good surface functionalization with high biocompatibility. The prominence of this technique is the possibility of merging low soluble drugs loaded in the nanofibers to enhance drug release and bioavailability. Incorporation of metal nanomaterials with electrocatalytic and/or plasmonic features into electrospun polymer nanofiber enhances thermodynamic and mechanical properties to obtain synergetic function and properties. This review comprehensively discusses an overview of theory of electrospinning, progress and concerns, and challenges currently face in fabricating efficient and effective drug delivery systems. Additionally, the drug-loaded into electrospun nanocarriers for drug delivery applications and insights into future prospects were explained.

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Section: Spinningmentioning

confidence: 99%

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Zare

Ramakrishna

2020

Proceedings of the 1st International Electronic Conference on Pharmaceutics

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“…Numerous polysaccharides could even adhere to the layer of mucus, which covers epithelial surfaces throughout the body. Thus, the polysaccharide based carrier systems have extended in vivo residence time in gastrointestinal (GI) tract, thereby increasing drug bioavailability [10][11][12][13][14]. Cationic polysaccharides such as chitosan and its derivatives have the capacity to open the tight interconnections among epithelial cells, thereby increased hydrophilic drug permeability through mucus membranes [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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“…Natural polysaccharides, with the attributes of good biocompatibility, degradability, easily soluble in water, low toxicity, and easy modi cation, have been more and more favored by researchers and widely used in the research of nano-drug delivery system [21][22][23]. As of now broadly utilized are hyaluronic corrosive (hyaluronic corrosive, HA), (chitosan, CS), Columbus polysaccharide, lentinan polysaccharide, angelica polysaccharide, and so forth [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Novel Dual CAFs and Cancer Cell Targeting Nano-Drug Delivery System for Anti-Fibrosis Mechanism of Liver Cancer

Guo

Hou

Liu

et al. 2021

Preprint

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This study proposed the construction of a delivery system based on dual targeting cancer-associated fibroblasts (CAFs) and tumor cell for the treatment of liver cancer. (Z-Glycine-Proline)-Hyaluronic Acid-Sulcanidone-Ginger Anone, named as GHSO, was an amphiphilic carrier material with dual pH/ROS sensitive and dual targeting properties that could be used to load hydrophobic drug to improve their solubility and enhance biocompatibility. Consequently, we combined paclitaxel (PTX) with GHSO to design a novel nano-micelles, called GHSO@PTX micelles. Also, we prepared a single targeted nano-micelles (Hyaluronic Acid-Sulcanidone-Ginger Anone) named HSO@PTX. The GHSO@PTX micelles was 159.40±14.30 nm-sized in neutral water. The electron microscopy results showed that the two micelles were relatively uniform in size and spherical in shape. The results of in vitro release experiments shown that GHSO@PTX micelles had better pH sensitivity and ROS responsiveness. Under the conditions of low pH/high H2O2 concentration, the cumulative release of micelles was the largest, which could achieve better therapeutic effects. Cell uptake, cytotoxicity of GHSO@PTX micelles were examined at different concentrations by using SMMC-7721 cells and CAFs. The 3D tumor ball experiment showed that GHSO@Cur micelles were more permeable than HSO@Cur, and proved the superiority of GHSO carrier. It first targeted CAFs cells, opened the physical barrier of tumor cells, and achieved deep penetration of tumor sites. We conducted pathological studies and immunohistochemical studies on isolated tissues and tumor tissue sections of nude mice, and investigated the safety and effectiveness of the preparations H&E staining confirmed its safety, Ki 67 was down-regulated, proving that tumor cell proliferation was inhibited, and the down-regulation of α-SMA and Masson proved that CAFs were inhibited and the preparation GHSO@PTX has the effect of killing CAFs and reducing the fibrosis of the tumor. A promising hyaluronic acid-based nanomedicine platform acts as a new drug delivery system to enhance the deep penetration effect of the tumor, and reduce the degree of fibrosis.

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Drug nanodelivery systems based on natural polysaccharides against different diseases

Cited by 97 publications

References 171 publications

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Current-status and applications of polysaccharides in drug delivery systems

Novel Dual CAFs and Cancer Cell Targeting Nano-Drug Delivery System for Anti-Fibrosis Mechanism of Liver Cancer

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