Drug pharmacomicrobiomics and toxicomicrobiomics: from scattered reports to systematic studies of drug–microbiome interactions

Aziz, Ramy K.; Hegazy, Shaimaa M; Yasser, Reem; Rizkallah, Mariam R; ElRakaiby, Marwa T.

doi:10.1080/17425255.2018.1530216

Cited by 39 publications

(28 citation statements)

References 114 publications

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“…Pharmacomicrobiomics encompasses not only the impact of single microbial species on drug fate and efficacy but also the impact of the whole microbial ecosystem . While there is considerable literature on the former, understanding of the relationship between the microbial community and drug efficacy/toxicity remains limited .…”

Section: Gut Microbiome Directly Influences Drug Efficacy and Toxicitymentioning

confidence: 99%

“…Experimental validation is another challenge faced while performing pharmacomicrobiomics surveys . While pharmacomicrobiomics will identify significant microbiome–drug interactions, it is not always possible to culture the bacteria of interest in the lab.…”

Section: Limitations Of Pharmacomicrobiomicsmentioning

confidence: 99%

“…Multidimensional data should include clinical data, diet, lifestyle, drugs, metagenomics, metatranscriptomics, metaproteomics, and metabolomics. Cohort development should also include consideration of ethnic groups, expanding to different countries, with higher sampling depth, to have an equitable human population representation . Overcoming these challenges, systematic and integrative pharmacomicrobiomics, along with increasing well‐characterized cohorts, will offer a great potential for the development of personalized therapies by combining personal microbiome and clinical profiling.…”

Section: Limitations Of Pharmacomicrobiomicsmentioning

confidence: 99%

“…[15][16][17] Pharmacomicrobiomics encompasses not only the impact of single microbial species on drug fate and efficacy but also the impact of the whole microbial ecosystem. 18 While there is considerable literature on the former, understanding of the relationship between the microbial community and drug efficacy/toxicity remains limited. 18 Two interdependent fields have emerged: pharmacometabolomics and pharmacometabonomics, 19,20 in which microbial metabolites are analyzed to determine associations with drug response.…”

mentioning

confidence: 99%

“…18 While there is considerable literature on the former, understanding of the relationship between the microbial community and drug efficacy/toxicity remains limited. 18 Two interdependent fields have emerged: pharmacometabolomics and pharmacometabonomics, 19,20 in which microbial metabolites are analyzed to determine associations with drug response. Pharmacometabolomics is the application of metabolomic technologies to this field, while pharmacometabonomics is the analysis of these data, including human genomics alongside the metabolomic data.…”

mentioning

confidence: 99%

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Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?

Sharma

Buschmann

Gilbert

2019

Clin Pharma and Therapeutics

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The human body, with 3.0 × 1013 cells and more than 3.8 × 1013 microorganisms, has nearly a one‐to‐one ratio of resident microbes to human cells. Initiatives like the Human Microbiome Project, American Gut, and Flemish Gut have identified associations between microbial taxa and human health. The study of interactions between microbiome and pharmaceutical agents, i.e., pharmacomicrobiomics, has revealed an instrumental role of the microbiome in modulating drug response that alters the therapeutic outcomes. In this review, we present our current comprehension of the relationship of the microbiome, host biology, and pharmaceutical agents such as cardiovascular drugs, analgesics, and chemotherapeutic agents to human disease and treatment outcomes. We also discuss the significance of studying diet–gene–drug interactions and further address the key challenges associated with pharmacomicrobiomics. Finally, we examine proposed models employing systems biology for the application of pharmacomicrobiomics and other ‐omics data, and provide approaches to elucidate microbiome–drug interactions to improve future translation to personalized medicine.

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Section: Gut Microbiome Directly Influences Drug Efficacy and Toxicitymentioning

confidence: 99%

Section: Limitations Of Pharmacomicrobiomicsmentioning

confidence: 99%

Section: Limitations Of Pharmacomicrobiomicsmentioning

confidence: 99%