Drug points: Exacerbation of angina associated with latanoprost

Mitra, Mario; Chang, Byung Chul; James, Ted A.

doi:10.1136/bmj.323.7316.783

Cited by 28 publications

(8 citation statements)

References 3 publications

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“…Angina [234], arterial hypertension [235,236] and tachycardia [235] have been anecdotally reported following initiation of latanoprost therapy in patients with glaucoma. In addition, three patients with open-angle glaucoma and no prior history of migraine and/or headache (age ‡ 54 years) reported migraine after receiving latanoprost treatment [237].…”

Section: Other Systemic Adverse Eventsmentioning

confidence: 99%

A review of the use of latanoprost for glaucoma since its launch

Digiuni

Fogagnolo

Rossetti

2012

Expert Opinion on Pharmacotherapy

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Latanoprost was the first prostaglandin analog introduced in glaucoma management and it dramatically changed the market of the disease thanks to its efficacy and safety. Conjunctival hyperemia, which is commonly found after latanoprost use, is associated with a minor efficacy and duration of trabeculectomy; yet, from the ophthalmologist's perspective, this side effect seems largely counterbalanced by the high efficacy and safety of this compound. It is always advisable to consider the pro-inflammatory mode of action of latanoprost because this may have negative effects in particular patients (i.e., those with uveitis and cystoid macular edema) for whom caution and close follow-up is necessary.

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Section: Other Systemic Adverse Eventsmentioning

confidence: 99%

A review of the use of latanoprost for glaucoma since its launch

Digiuni

Fogagnolo

Rossetti

2012

Expert Opinion on Pharmacotherapy

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“…Other systemic events, each with an incidence of 1 or 2%, included chest pain/angina, muscle/joint/back pain and rash/allergic skin reaction. Angina, arterial hypertension, and tachycardia have been anecdotally reported following latanoprost use 92,93. In a randomized study, headache was more frequent in patients receiving latanoprost than in those receiving bimatoprost although this difference did not reach statistical significance 6.…”

Section: Systemic Side Effects Of Bimatoprostmentioning

confidence: 99%

Bimatoprost in the treatment of eyelash hypotrichosis

Law¹

2010

OPTH

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Eyelashes hypotrichosis is a condition indicated by an inadequate amount of eyelashes. Hypertrichosis of eyelashes, characterized by excessive eyelash growth, is a regular phenomenon associated with ophthalmic prostaglandin and prostamide analogs. Recently, the US Food and Drug Administration approved Latisse® (bimatoprost 0.03% solution), identical to the ophthalmic solution for glaucoma treatment, for increasing eyelash length, thickness and darkness in patients with hypotrichosis of the eyelashes. When prostaglandin and prostamide analogs interact with the prostanoid receptors in the hair follicle, this most likely stimulates the resting follicles (telogen phase) to growing follicles (anagen phase). Prostaglandin and prostamide analogs may also prolong the anagen phase of eyelashes, leading to an increase of eyelash length. Although bimatoprost is effective in promoting increased growth of healthy eyelashes and adnexal hairs, its effectiveness in patients with eyelash alopecia areata is debatable and its protective effect is not yet studied in patients with eyelash loss secondary to radiation or chemotherapy. Bimatoprost is generally safe when applied to the base of the eyelashes at the lid margin with minimum side effects. However, other ocular or systemic side effects associated with ophthalmic prostaglandin and prostamide analogs may occur when instilled on the surface of the eye, and patients must be informed and monitored.

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“…In some patients with glaucoma alteration in the hemodynamic parameters of the extraocular vessels could be observed [14]. Although the in vivo vasoconstrictive effect of latanoprost is still debated [15,16], it is worth mentioning that latanoprost has recently been reported to be associated with exacerbation of angina pectoris [17]. One cannot exclude that a similar effect could potentially occur in the ocular circulation of glaucoma patients that have some vascular dysregulations.…”

Section: Discussionmentioning

confidence: 99%