Drug points: Parotid swelling and terbinafine

Torrens, J.K.; McWhinney, Paul

doi:10.1136/bmj.316.7129.440a

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…15 A few cases were associated to a rash, but without hypereosinophilia. 16,17 Only one case of terbinafine-induced parotitis has been reported in the literature, 18 with no evidence of DRESS.…”

Section: Discussionmentioning

confidence: 98%

Severe sialadenitis: A new complication of drug reaction with eosinophilia and systemic symptoms

Abecassis¹,

Roujeau²,

Bocquet³

et al. 2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 98%

Severe sialadenitis: A new complication of drug reaction with eosinophilia and systemic symptoms

Abecassis¹,

Roujeau²,

Bocquet³

et al. 2004

Journal of the American Academy of Dermatology

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“…Drug induced parotid enlargement is less common and is reported with drugs such as clonazepam, clozapine, butazones, bretylium, asparaginase, methyldopa, iodide preparations and terbinafine. [12,13] Further, hypersensitivity reactions associated with xerostomia following oysters intake, mercury and lead poisoning would also lead to parotid swelling. [14] Ross et al has demonstrated that naturally derived calcium supplements including oyster shell contains significant amount of lead.…”

Section: Discussionmentioning

confidence: 99%

Oyster shell calcium induced parotid swelling

Palaniappan

Selvarajan

Srinivasamurthy

et al. 2014

Journal of Pharmacology and Pharmacotherapeutics

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A 59 year old female consumer was started on therapy with oyster shell calcium in combination with vitamin D3 and she presented with swelling below the ear, after two doses. She stopped the drug by herself and the swelling disappeared in one day. She started the drug one day after recovery and again she developed the swelling. She was advised to stop the drug with a suggestion to take lemon to enhance parotid secretion and the swelling subsided. Calcium plays major role in salivary secretion and studies have shown reduced parotid secretion in rats, deficient of vitamin D. But in humans involvement of calcium and vitamin D3 in parotid secretion is unknown. However, the patient had no history of reaction though she had previously taken vitamin D3 with calcium carbonate which was not from oyster shell. Hence, we ruled out vitamin D3 in this reaction and suspecting oyster shell calcium as a culprit. This adverse drug reaction (ADR) was assessed using World Health Organization (WHO) causality assessment, Naranjo's and Hartwig severity scales. As per WHO causality assessment scale, the ADR was classified as “certain”. This reaction was analyzed as per Naranjo's algorithm and was classified as probable. According to Hartwig's severity scale the reaction was rated as mild. Our case is an example of a mild but rare adverse effect of oyster shell calcium carbonate which is widely used.

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Parotiszwelling door terbinafine

1999

MFAM

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Drug points: Parotid swelling and terbinafine

Cited by 10 publications

References 4 publications

Severe sialadenitis: A new complication of drug reaction with eosinophilia and systemic symptoms

Severe sialadenitis: A new complication of drug reaction with eosinophilia and systemic symptoms

Oyster shell calcium induced parotid swelling

Parotiszwelling door terbinafine

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