Drug Prescription Pattern of Breast Cancer Patients in a Tertiary Care Hospital in West Bengal: A Cross-Sectional and Questionnaire-Based Study

Adhikari, Anjan; Chakraborty, Dipesh; Indu, Rania; Bhattacharya, Sangita; Ray, Moumita; Mukherjee, Ramanuj

doi:10.22159/ajpcr.2018.v11i3.23180

Cited by 3 publications

(6 citation statements)

References 11 publications

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“…Triple negative carcinoma accounted for 27.14% of the present study population which was in line with previous studies from North and South India, where the percentages were 18% and 31.5% respectively. 11,18,19 Among the different forms of breast cancer observed in the present study, the most prominent histopathological type was infiltrating ductal carcinoma, accounting to 87.62% of the study population. This was supported by another study that highlighted infiltrating ductal carcinoma was the most common form of breast cancer, representing about 85 of total cases in which 39 were premenopausal and 46 were postmenopausal women, which agrees with the previous reported studies.…”

Section: Discussionmentioning

confidence: 61%

“…This is in accordance with previous epidemiological studies where the prevalence of breast cancer was higher in postmenopausal women. 10,11 As reported in most of the previous studies, majority of the patients (53.92%) were diagnosed at high-grade carcinomas with higher Ki67 expression (≥14%). 12 This reflects that the population lacked awareness of the disease and worse the disease condition.…”

Section: Discussionmentioning

confidence: 74%

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A retrospective, epidemiological study on the pattern of distribution of phenotypic subgroups among patients of breast cancer in a tertiary care level hospital of West Bengal, India

et al. 2020

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Background: The burden of breast cancer is increasing worldwide and it is second most cause of mortality in India. Epidemiologic data regarding different phenotypic subgroups in Indian women is scarce. The present study aimed to find out the epidemiological distribution of different phenotypic subgroups in the patients suffering from breast cancer.Methods: This was a retrospective, observational study conducted at the Department of Radiotherapy, Burdwan Medical College and Hospital, West Bengal, India between July 2012 and June 2017. Women diagnosed with biopsy proven breast carcinoma who had been attending radiation oncology outdoor patients department (OPD) were included in the study. The data of the patients regarding age at presentation, grade of tumor, Ki 67 status, hormone receptor status, and their phenotypic subgroup classification were retrieved from hospital record.Results: A total of 280 women patients were included in the study, of these, 105 were premenopausal and 175 were postmenopausal. Locally advanced breast cancer (60.0%) was most prevalent breast cancer among them. Majority of the patients had grade III tumor and higher expression of Ki-67 index at the time of presentation (53.92% and 68.21%, respectively). Infiltrating Ductal carcinoma is the most prevalent histopathological sub-type in both premenopausal and postmenopausal women. Hormone receptor positivity in premenopausal women was comparatively higher than postmenopausal women. Whereas human epidermal growth factor receptor 2 negative cancer was comparatively higher in postmenopausal women (66.98%). The most prevalent phenotypic subgroup among premenopausal and postmenopausal group was luminal B (38.09%) and luminal A (36.57%), respectively.Conclusions: Overall findings suggest that majority of patients were diagnosed with high grade and high Ki67 index which showed lack of awareness in these patients about this disease. Use of prognostic factors and predictive markers can be helpful to diagnose breast cancer at early life.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 74%

A retrospective, epidemiological study on the pattern of distribution of phenotypic subgroups among patients of breast cancer in a tertiary care level hospital of West Bengal, India

et al. 2020

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“…Reports on the age of menarche show that 102 of patients with late menarche (51%), 62 of the patients with average menarche (31%) and 36 of patients with early menarche (18%). A similar study was conducted by Anjan Adhikari et al (2018).…”

Section: Discussionmentioning

confidence: 72%

“…Stage II cancer can be treated by chemotherapy, radiation or surgery. [5] Stage II A ≤ 2 cm and has not spread to lymph nodes or 2-5 cm and has spread to 1-3 lymph nodes.…”

Section: Stage IImentioning

confidence: 99%

A Multicentric non-interventional observational study to determine treatment patterns and response of drugs in various stages of breast cancer along with epidemiology

Niharika¹,

Kulsumbi²,

Anupama³

et al. 2020

ijprls

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Cancer is a life-threatening disease which causes to lose cohesiveness and orderliness of normal tissue. These malignant cells can spread to any other organ through blood flow or lymphatic flow and develop malignancy over there; this phenomenon is called metastasis. The aim is to focus on treatment pattern and response of drugs in various stages of breast cancer along with epidemiology. It is a non- interventional multicentric observational study. Female patients confirmed with Breast cancer are included in the study. All the relevant data were collected on a patient demographic form after obtaining informed consent from individual patients. In our study, the mean age of presentation in breast cancer patients was 41.35 years. Further it was found that 40.5% (n = 81) majority-female patients with Breast cancer are from Guntur District and 21.5% (n= 43). The majority of women with Breast cancer have hormone receptor expression of ER+/PR+HER2- was found to be 33% (n= 50). In the study on analyzing comorbidities of the study population, it was noted that 28.5% of women were affected with Diabetes mellitus. In our study, it was found that most of the patients with Breast cancer have been most often prescribed with Adriamycin 27.86%. From these observations, we conclude that late menarche may be one of the etiological causes of breast cancer in women, Invasive carcinoma in situ is the most commonly reported breast cancer in the study. Patients have been diagnosed with breast cancer at their stage 3 of progression, which may be the reason for making it mandatory for more than 50% of patients to undergo 6 to 8 cycles of chemotherapy. Coming to the patterns of drug use, ADRIAMYCIN, CYCLOPHOSPHAMIDE and DOCETAXEL are the three most commonly used single drug and combinational drug therapies among the study population.

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“…• 3-5 points: Grade I -Well differentiated • 6-7 points: Grade II -Moderately differentiated • 8-9 points: Grade III -Poorly differentiated (Adhikary, 2018) Most breast cancers are diagnosed as small tumors within a range less than or equal to 2cm. It mostly gets diagnosed at early stages.…”

Section: Introductionmentioning

confidence: 99%

Insights of Breast Cancer and Barriers to its Therapy

Garg

Baishnab

Das

et al. 2019

JPTRM

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Breast cancer is the most common cancer across the globe occurring commonly in women population, and it is one of the main causes of mortality in women. In 2018, 1,62,468 new cases and 87,090 death cases of breast cancer were registered in India. In these recent years, lots of studies were conducted in breast cancer related to treatment and management, but in spite of getting so much advancement in the treatment of breast cancer still, the mortality rate of women is increasing day by day. Numerous factors are acting as barriers or challenges in breast cancer preventive therapy. It includes lack of knowledge regarding the treatment of cancer and patient getting insecure about treatment, fear of having side effects, cost of treatment and the efficacy of the drugs being prescribed. The study intended to determine the perceived insights and barriers to treatment of breast cancer.

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Drug Prescription Pattern of Breast Cancer Patients in a Tertiary Care Hospital in West Bengal: A Cross-Sectional and Questionnaire-Based Study

Cited by 3 publications

References 11 publications

A retrospective, epidemiological study on the pattern of distribution of phenotypic subgroups among patients of breast cancer in a tertiary care level hospital of West Bengal, India

A retrospective, epidemiological study on the pattern of distribution of phenotypic subgroups among patients of breast cancer in a tertiary care level hospital of West Bengal, India

A Multicentric non-interventional observational study to determine treatment patterns and response of drugs in various stages of breast cancer along with epidemiology

Insights of Breast Cancer and Barriers to its Therapy

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