Drug Profile: Benoral

Abstract

Benorylate, an esterification product of paracetamol and acetylsalicylic acid is indicated in the treatment of rheumatoid and osteo-arthritis, other painful conditions and febrile states. In animals benorylate’ has been shown to be of low toxicity and only has teratogenic activity at high doses. Gastric effects are less severe than occur with aspirin. Analgesic, anti-inflammatory and anti-pyretic effects have been demonstrated in animal models. Benorylate is well absorbed and metabolised to paracetamol and aspirin producing higher steady state levels than that with paracetamol alone. In man the half life is about one hour. Clinically, benorylate has been shown to be comparable with aspirin in the treatment of rheumatoid arthritis, osteo-arthritis and other painful conditions. It shows better gastric tolerance than aspirin and is less likely to produce gastro-intestinal bleeding. A prolonged anti-pyretic effect has been demonstrated.

Vasomotor Rhinitis Treated With Lunerin® (Draco), a New Sympathomimetic Antihistaminic Preparation

“…Each of the components in the tested preparation has previously been demonstrated to have an effect on allergic and vasomotor troubles, both in uncontrolled (Boyer 1938, Murphy 1939, Ftichs & Maurer 1959 and controlled studies {Schiller et al i()^(), Mafl,aren 1959).…”

Exploring acetaminophen prodrugs and hybrids: a review

“…First ester, – 4-acetamido-phenyl-2-acetoxybenzoate 46 , is known as benorylate drug (Benoral®, Benortan®). 112,113 Its initial hydrolysis of the acetyl group yields a minor metabolite ester 47 , known as acetaminosalol. Its ester bond is enzymatically degradable in the body to produce two active metabolites, acetylsalicylic acid 9 or APAP.…”

Clinical Evaluation of an Oral Combined Antihistaminic Sympathomimetic Preparation

“…Clinically, the preparation is used in a pure form in allergic rhinitis, where it diminishes nasal obstruction by virtue of its vasoconstrictor effect and gives good symptomatic relief. It has given equally good effect when administered orally or locally in the nose (3,4,18,23). Both compounds, brompheniramine and phenylpropanolamine, are released successively from the Lunerin tablet, which forms a porous plastic matrix.…”