Drug reaction with eosinophilia and systemic symptoms in pediatric patients: A clinicopathological study of 16 cases in the National Center of Pharmacovigilance of Tunisia

Drug reaction with eosinophilia and systemic symptoms in a paediatric population: Interest of skin tests

“…In the medical literature, 11 case series of paediatric DRESS, including at least 10 children, have been published until now. 5,[12][13][14][15][16][17][18][19][20][21] The largest one by Bedouelle et al 21 included 49 patients. Table 4 highlights the similarities and differences between these studies.…”

“…Conversely, according to a Tunisian series involving 16 paediatric DRESS cases, 68.7% were related to anticonvulsant agents. 20 The time between drug exposure and the onset of DRESS first symptoms ranges from 2 and 6 weeks. 23 In our series, the median delay between drug intake and symptoms was 21 days, which is similar to latency periods in the studies of Kaabi et al 20 and Han et al 18 However, Ahluwalia et al 15 reported a shorter interval (9 days).…”

“…In our series, we have analysed the clinical and biological features of 19 paediatric DRESS developed in 18 patients. In the medical literature, 11 case series of paediatric DRESS, including at least 10 children, have been published until now 5,12–21 . The largest one by Bedouelle et al 21 included 49 patients.…”

Carbamazepine‐induced liver injury in an 11‐year‐old female: Case report and review of the literature

“…A study in Tunisia identified 16 patients with DRESS where the most common offending drugs were anticonvulsants and noted the liver as the most common organ affected. 16 Dapsone was reported to lead to a hypersensitivity reaction resulting in fulminant hepatitis requiring liver transplant in a 12-year-old patient. 17 A review over 13 years in India found that paediatric cases of DILI accounted for 8.7% of all cases occurring in that timeframe (39 children total), and was most commonly caused by anti-tuberculous drugs, and secondarily by anti-convulsant drugs.…”

“…Our patient's clinical course was consistent with a prolonged biphasic DRESS, which has not been commonly described in children. A study in Tunisia identified 16 patients with DRESS where the most common offending drugs were anticonvulsants and noted the liver as the most common organ affected 16 . Dapsone was reported to lead to a hypersensitivity reaction resulting in fulminant hepatitis requiring liver transplant in a 12‐year‐old patient 17 .…”