Drug Reactions to the Sulfones

Comparison Between Intravenous Immunoglobulin and Conventional Immunosuppressive Therapy Regimens in Patients With Severe Oral Pemphigoid

“…19 Since the first report of its use in a few patients with bullous pemphigoid in 1985, 20 several investigators have reported on its efficacy in the therapy of both bullous pemphigoid and pemphigus vulgaris. 11,[21][22][23][24][25][26][27][28] Our retrospective study describes 20 patients with involvement of the oral cavity who were observed between September 1, 1994, and October 31, 2000. Since topical therapy was ineffective, dapsone therapy was initiated.…”

“…The profile of adverse effects of the drugs used is well known. 11,17,20,28,29 Adverse effects of longterm usage of systemic corticosteroids such as moon faces, buffalo humps, and redistribution of body adipose tissue were excluded from Table 2. The reason for this was that these adverse effects did not necessitate medical therapy, although bothersome to the patient.…”

Dapsone-Induced Haemolytic Anaemia and Agranulocytosis in a Patient with Normal Glucose-6-Phosphate-Dehydrogenase Activity

“…Its multiple toxic effects include haematological, dermatological, renal, neurological and gastrointesti nal manifestations [3,4]. Dapsone-induced haemo lytic anaemia is a common unwanted side effect and patients with glucose-6-phosphate-dehydrogenase (G6PD) deficiency are more susceptible [5][6][7].…”

Dapsone-Induced Distal Axonal Degeneration of the Motor Neurons

“…Dapsone (4,4'-diaminodiphenyl sulfone) has in recent years been increas ingly used in the therapy of various dermatologic disorders [6]. Serious side effects attributable to sulfones are most often dermatological disturbances like hemolysis, methemoglobinemia, neutropenia and agranulocytosis.…”

“…Serious side effects attributable to sulfones are most often dermatological disturbances like hemolysis, methemoglobinemia, neutropenia and agranulocytosis. In addition, reactions to sulfones include anorexia, jaundice, skin eruptions, psychoses and headache [6], Polyneuropathy after the prolonged use of this drug has been reported in 10 patients [1-4, 7-10, 13]. Motor symptoms pre dominate, especially weakness and atrophy of the intrinsic hand muscles [1-4, 7, 8, 13].…”