Drug related deaths between 2008 and 2011. A retrospective study in 32 Romanian counties

Dermengiu, Dan; Hostiuc, Sorin; Radu, Doina; Aciu, Florina; Gorun, Gabriel; Astărăstoae, Vasile; Ioan, Beatrice Gabriela; Constantinescu, Gabriela; Enache, Alexandra; Ciocan, Veronica; Talos, Ioan; Curcă, George Cristian

doi:10.2478/s11536-013-0190-5

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last years, in Romania was developed a research regarding the drug related deaths. The toxicological analysis indicated the presence of barbiturates, benzodiazepines, cannabinoids and opiates in about 55% of cases [1].…”

Section: Introductionmentioning

confidence: 99%

Influence of Internal Structure of the Sorbents on Diazepam Sorption from Simulated Intestinal Fluid

Stefan

Negoita

et al. 2021

Applied Sciences

View full text Add to dashboard Cite

The capacity of natural Na-montmorillonite and activated charcoal for sorption of diazepam from simulated intestinal fluid (SIF) was studied. The main characteristics of the sorbents were determined. In order to characterize the sorption process of diazepam the influence of the pH, contact time and ethanol presence in SIF was analyzed. Adsorption isotherms for the diazepam-activated charcoal and diazepam-natural Na-montmorillonite systems were determined. The Langmuir isotherm model provided a very good description of diazepam sorption. Furthermore, the pH-drift method was used to determine the specific pH at zero point of charge (pHzpc) of the sorbents. The obtained results show that the internal structure of the sorbents and pH of the SIF solutions are very important for diazepam sorption. Both the surface of the activated charcoal and natural Na-montmorillonite are positively charged below the pHzpc so the sorption of diazepam is higher below this point and occur by van der Waals forces. The presence of ethanol in simulated intestinal fluid lowers the adsorption of diazepam on both sorbents.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of Internal Structure of the Sorbents on Diazepam Sorption from Simulated Intestinal Fluid

Stefan

Negoita

et al. 2021

Applied Sciences

View full text Add to dashboard Cite

show abstract

Pattern of benzodiazepine use among death cases in Republic of North Macedonia

Bujaroska,

Bozhinoska,

Bitoljanu

et al. 2021

Maced. Pharm. Bull.

View full text Add to dashboard Cite

The aim of this study was to determine the pattern of benzodiazepine related deaths in Republic of North Macedonia. Retrospective survey of post-mortem toxicology data from eight-year period, obtained from Laboratory of Forensic Toxicology was performed, including cases with known gender, age, cause and manner of death and complete toxicology report. Post-mortem toxicology analyses were conducted with Fluorescence Polarization/Enzymatic Immunoassay and Biochip Array Technology method for screening of urine and blood respectively, and confirmation by GC-MS after solid phase extraction. Total of 1169 cases were investigated. Benzodiazepines were detected in 30.05% of the cases, with statistically significant difference between cases of natural and of violent cause of death, as well as between genders, but without statistically significant difference due to the age between both genders. Study revealed women were more likely to use benzodiazepines with the median age to be 52.88 and 49.87 for males and females, respectively. According to post-mortem toxicology data benzodiazepines are the most used drugs in our country. Of them, diazepam was found to be the most often used one. Data analyses have shown that benzodiazepines were often combined with alcohol, psychoactive medicines and drugs of abuse. In 46.6% of all cases with positive findings for benzodiazepines, use of drugs of abuse was detected, mostly heroine and methadone. Important note should be given to the simultaneous use of benzodiazepines with heroine and methadone, which have resulted in increased number of fatal intoxications. Further studies are needed to determine the reason for popular use of benzodiazepines among drug addicts. Keywords: Abuse, diazepam, drug-related deaths, intoxication, post-mortem

show abstract

Drug related deaths between 2008 and 2011. A retrospective study in 32 Romanian counties

Cited by 2 publications

References 18 publications

Influence of Internal Structure of the Sorbents on Diazepam Sorption from Simulated Intestinal Fluid

Influence of Internal Structure of the Sorbents on Diazepam Sorption from Simulated Intestinal Fluid

Pattern of benzodiazepine use among death cases in Republic of North Macedonia

Contact Info

Product

Resources

About