Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Offor, Ifeanyichukwu; Awodele, Olufunsho; Oshikoya, Kazeem Adeola

doi:10.1002/prp2.452

Cited by 7 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Offor et al documented the impact of drug treatment of maternal illnesses during pregnancy in the etiology of congenital anomalies [29]. Only about one-fifth of the patients in the present study had a prenatal diagnosis of their pathology.…”

Section: Discussioncontrasting

confidence: 51%

Profile of Congenital Genitourinary Anomalies in the Two Teaching Hospitals in Enugu, Nigeria

Emeka¹,

Ikemefuna

2021

BJSTR

View full text Add to dashboard Cite

Background: Congenital anomalies of the urogenital system are some of the most common birth defects affecting children. The aim of this study was to evaluate the prevalence and types of congenital genitourinary anomalies seen in the 2 teaching hospitals in Enugu, Nigeria. Materials and Methods:This was an observational study carried out on babies at the two teaching hospitals in Enugu. The newborns were examined for congenital genitourinary anomalies and the study covered a period of 5 years.Results: There were 17,241 babies delivered in the 2 teaching hospitals during the study period. Overall, 328 babies had at least one congenital anomaly which gave an overall incidence of all congenital anomalies of 1.9% or 19 babies per 1000 live births. Out of the 328 babies that had congenital anomalies, 93 babies had a genitourinary anomaly. This gave an incidence of 0.5% or 5 babies per 1000 live births. There was female predominance and majority of the babies were preterm and weighed less than 2.5 kilograms. Hypospadias was the most common genitourinary anomaly and only a few of the anomalies were diagnosed prenatally. Half of the mothers took herbal concoction during their pregnancy and about one-fifth of them had gestational diabetes/ hypertension. Conclusion:Genitourinary anomaly is a common birth defect that is may be associated with some morbidity. Hypospadias is the most common abnormality in the present study and half of the mothers took herbs.

show abstract

Section: Discussioncontrasting

confidence: 51%

Profile of Congenital Genitourinary Anomalies in the Two Teaching Hospitals in Enugu, Nigeria

Emeka¹,

Ikemefuna

2021

BJSTR

View full text Add to dashboard Cite

show abstract

“…Eight (23.5%) of the 34 papers on prevention focused on folic acid, most commonly reporting on the use of folic acid by mothers in the context of NTD and hydrocephalus (e.g., [ 22 , 105 , 123 , 124 , 132 , 164 ]). Four papers focused on barriers to [ 34 ], awareness of the benefit of [ 49 ], and estimation of potential reduction in the rate of NTD and hydrocephalus due to folic acid use [ 94 ]; and modelling of potential prevention of under-5 mortality [ 94 ].…”

Section: Resultsmentioning

confidence: 99%

“…Six papers focused solely on rubella or rubella vaccination [ 60 , 129 , 145 , 176 , 232 , 249 ], addressing rubella infection prevalence among women, immunity in adolescents, screening, and the baseline prevalence of congenital rubella syndrome prior to the introduction of immunization (60). A further 17 papers mentioned rubella or rubella vaccination but did not collect specific data [ 26 , 34 , 55 , 64 , 70 , 73 , 78 , 83 , 88 , 123 , 153 , 164 , 165 , 192 , 238 , 242 , 244 ]. One paper investigated the emergence and circulation of Zika virus in SSA [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

“…The two main categories of risk factors investigated were medication safety in pregnancy (n = 8, [ 70 , 96 , 99 , 100 , 123 , 159 , 164 , 207 ]), and environmental pollution (n = 6). Most medication safety studies evaluated a series of medications (including herbal) as part of a general CA risk factor assessment [ 70 , 96 , 123 , 164 ], while a few evaluated the safety of a single medication type/class (antiretrovirals [ 99 , 100 ] and antimalarials 207) or general medication use in pregnancy [ 159 ]. There were no papers on common medicines used for non-infectious diseases, or on the impact of vaccination during pregnancy.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The burden, prevention and care of infants and children with congenital anomalies in sub-Saharan Africa: A scoping review

Leke,

Malherbe,

Kalk

et al. 2023

PLOS Glob Public Health

View full text Add to dashboard Cite

The aim of this scoping review was to determine the scope, objectives and methodology of contemporary published research on congenital anomalies (CAs) in sub-Saharan Africa (SSA), to inform activities of the newly established sub-Saharan African Congenital Anomaly Network (sSCAN). MEDLINE was searched for CA-related articles published between January 2016 and June 2021. Articles were classified into four main areas (public health burden, surveillance, prevention, care) and their objectives and methodologies summarized. Of the 532 articles identified, 255 were included. The articles originated from 22 of the 49 SSA countries, with four countries contributing 60% of the articles: Nigeria (22.0%), Ethiopia (14.1%), Uganda (11.7%) and South Africa (11.7%). Only 5.5% of studies involved multiple countries within the region. Most articles included CA as their primary focus (85%), investigated a single CA (88%), focused on CA burden (56.9%) and care (54.1%), with less coverage of surveillance (3.5%) and prevention (13.3%). The most common study designs were case studies/case series (26.6%), followed by cross-sectional surveys (17.6%), retrospective record reviews (17.3%), and cohort studies (17.2%). Studies were mainly derived from single hospitals (60.4%), with only 9% being population-based studies. Most data were obtained from retrospective review of clinical records (56.1%) or via caregiver interviews (34.9%). Few papers included stillbirths (7.5%), prenatally diagnosed CAs (3.5%) or terminations of pregnancy for CA (2.4%).This first-of-a-kind-scoping review on CA in SSA demonstrated an increasing level of awareness and recognition among researchers in SSA of the contribution of CAs to under-5 mortality and morbidity in the region. The review also highlighted the need to address diagnosis, prevention, surveillance and care to meet Sustainable Development Goals 3.2 and 3.8. The SSA sub-region faces unique challenges, including fragmentation of efforts that we hope to surmount through sSCAN via a multidisciplinary and multi-stakeholder approach.

show abstract

“…Japanese patients had a higher frequency of cardiovascular anomalies than American and Egyptian patients, and a female predominance was also observed [15]. Previous experiments reported several medications, such as anti-epileptics, anti-convulsants, and antihypertensive, implicated in neural tube defects, cardiovascular, gastrointestinal, and urinary tract DAs [16].…”

Section: Introductionmentioning

confidence: 91%

Developmental anomalies and associated impairments in Saudi children with cerebral palsy: a registry-based, multicenter study

Al-Garni¹,

Derbala

Saad

et al. 2021

Egypt Rheumatol Rehabil

View full text Add to dashboard Cite

Background There are few epidemiological data to support rehabilitation programs for cerebral palsy (CP). Scarce international studies described the developmental anomalies (DAs) among children with CP. To our knowledge, the Arab countries did not publish data regarding this topic. This study aimed to describe the percentage of DAs among children with CP and detect the association between clinical subtypes and impairment severity in children with various DAs. We collected registry data of 679 children with cerebral palsy, between 2014 and 2019, from Armed Forces Hospitals, Taif, Kingdom of Saudi Arabia (KSA). We recorded demographic, perinatal, postnatal, developmental anomalies, subtypes, and impairment characteristics. We utilized the chi-square test to calculate the differences between groups. Results We reported significant differences between the children with and without anomalies regarding the percentages of consanguinity, preterm labor, low birth weight, and neonatal intensive care unit admission (P = 0.001, 0.002, 0.003, 0.005, respectively). Congenital dysplasia of the hip and hydrocephalus was the most frequent skeletal and nervous anomalies among children with DAs (19.1% and 12.8%, respectively). The spastic bilateral pattern was significantly higher among children with skeletal anomalies than the central nervous system/other groups (P < 0.001). The nervous anomalies group had higher frequencies of severe intellectual, motor, speech, and visual disabilities and a higher percentage of seizures than all other groups. Conclusions The frequency of children with anomalies in this study was comparable to previous studies. Children with CP and nervous system anomalies had more severe motor disabilities and associated impairments.

show abstract

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Cited by 7 publications

References 31 publications

Profile of Congenital Genitourinary Anomalies in the Two Teaching Hospitals in Enugu, Nigeria

Profile of Congenital Genitourinary Anomalies in the Two Teaching Hospitals in Enugu, Nigeria

The burden, prevention and care of infants and children with congenital anomalies in sub-Saharan Africa: A scoping review

Developmental anomalies and associated impairments in Saudi children with cerebral palsy: a registry-based, multicenter study

Contact Info

Product

Resources

About