Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics

Bi, Hongmei; Chen, Zeqin; Qiu, Jiaqin

doi:10.1080/15685551.2021.1929684

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…The formation of the vesicles/liposomes is made possible by extrusion, if the processes take place at a temperature higher than their phase transition temperature such that the lipids are in a fluid state. [ 34–37 ] While commonly utilized as a strategy for formulating liposomes, to our knowledge, the work presented here is the first to demonstrate the ability to form stable monodisperse gas‐core nanostructures using the mini‐extruder system.…”

Section: Introductionmentioning

confidence: 99%

Extrusion: A New Method for Rapid Formulation of High‐Yield, Monodisperse Nanobubbles

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Perera

et al. 2022

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Shell‐stabilized gas microbubbles (MB) and nanobubbles (NB) are frequently used for biomedical ultrasound imaging and therapeutic applications. While it is widely recognized that monodisperse bubbles can be more effective in these applications, the efficient formulation of uniform bubbles at high concentrations is difficult to achieve. Here, it is demonstrated that a standard mini‐extruder setup, commonly used to make vesicles or liposomes, can be used to quickly and efficiently generate monodisperse NBs with high yield. In this highly reproducible technique, the NBs obtained have an average diameter of 0.16 ± 0.05 µm and concentration of 6.2 ± 1.8 × 1010 NBs mL−1 compared to 0.32 ± 0.1 µm and 3.2 ± 0.7 × 1011 mL−1 for NBs made using mechanical agitation. Parameters affecting the extrusion and NB generation process including the temperature, concentration of the lipid solution, and the number of passages through the extruder are also examined. Moreover, it is demonstrated that extruded NBs show a strong acoustic response in vitro and a strong and persistent US signal enhancement under nonlinear contrast enhanced ultrasound imaging in mice. The extrusion process is a new, efficient, and scalable technique that can be used to easily produce high yield smaller monodispersed nanobubbles.

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Section: Introductionmentioning

confidence: 99%

Extrusion: A New Method for Rapid Formulation of High‐Yield, Monodisperse Nanobubbles

Counil

Abenojar

Perera

et al. 2022

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“…Multiple drug carriers including bacteria, , viruses, liposomes, , phenylenediamine, exosomes, microcapsules, , nanoniosomes, and various nanoparticles have been widely reported. These can be modified to turn them specific against a given cancer, aiming at the development of targeted drug delivery solutions .…”

Section: Introductionmentioning

confidence: 99%

Acid-Directed Electrostatic Self-Assembly Generates Charge-Reversible Bacteria for Enhanced Tumor Targeting and Low Tissue Trapping

Feng

Liu

Pan

et al. 2022

ACS Appl. Mater. Interfaces

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Despite recent preclinical progress with oncolytic bacteria in cancer therapy, dose-limiting toxicity has been a longstanding challenge for clinical application. Genetic and chemical modifications for enhancing the bacterial tumor-targeting ability have been unable to establish a balance between increasing its specificity and effectiveness while decreasing side effects. Herein, we report a simple, highly efficient method for rapidly self-assembling a clinically used lipid on bacterium and for reducing its minimum effective dose and toxicity to normal organs. The resultant bacteria present the ability to reverse-charge between neutral and acidic solutions, thus enabling weak interactions with the negatively charged normal cells, hence increasing their biocompatibility with blood cells and with the immune system. Additionally, the lipid-coated bacteria exhibit a longer blood circulation lifetime and low tissue trapping compared with the wild-type strains. Thereby, the engineered bacteria show enhanced tumor specificity and effectiveness even at low doses. Multiple visualization techniques are used for vividly demonstrating the time course of bacterial circulation in the blood and normal organs after intravenous administration. We believe that these methods for biointerfacial lipid self-assembly and evaluation of bacterial systemic circulation possess vast potential in exquisitely fabricating engineered bacteria for cancer therapy in the future.

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Fabrication, modification and application of lipid nanotubes

Chen²,

Guo³

et al. 2022

Chemistry and Physics of Lipids

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Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics

Cited by 5 publications

References 25 publications

Extrusion: A New Method for Rapid Formulation of High‐Yield, Monodisperse Nanobubbles

Extrusion: A New Method for Rapid Formulation of High‐Yield, Monodisperse Nanobubbles

Acid-Directed Electrostatic Self-Assembly Generates Charge-Reversible Bacteria for Enhanced Tumor Targeting and Low Tissue Trapping

Fabrication, modification and application of lipid nanotubes

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