Drug release behavior of poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA) prepared by direct polycondensation

Shi, Gang; Ding, Yuanyuan; Zhang, Xin; Wu, Luyan; He, Fei; Ni, Caihua

doi:10.1080/09205063.2015.1080456

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…21,22 Kulkarni et al 23 reported that the glutaraldehyde cross-linked SA/polyvinyl alcohol hydrogels are sustained drug release whereas native SA/polyvinyl alcohol hydrogels are discharged the drug quickly. Shi et al 24 reported that poly(lactic-glycolic acid) grafting from SA showed a high drug loading rate and prolonged drug release speed of the sodium alginate-grafting-poly (lactic-glycolic acid) (ALG-g-PLGA) gel microspheres.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

Obireddy

Subha

Jithendra

et al. 2020

Polymers and Polymer Composites

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This article reports the fabrication of pH-sensitive microbeads from sodium alginate (SA) and modified karaya gum (KG). KG was modified by graft copolymerization using 2-hydroxyethyl methacrylate (2-HEMA) through in situ free radical polymerization reaction. The graft copolymer was blended with SA to develop microbeads by a simple ionotropic gelation technique. The microbeads were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and scanning electron microscopy. The effect of %HEMA and polymer blend ratio on the swelling capacity was investigated. Drug release kinetics of the microbeads was investigated under both pH 7.4 and pH 1.2 at 37°C. The drug release kinetics was analyzed by evaluating the release data using different kinetic models.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

Obireddy

Subha

Jithendra

et al. 2020

Polymers and Polymer Composites

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“…Meanwhile, the absorption peaks alkyl C−H and C=C stretch, aromatic C=C bending and stretching, and CH−NH−C=O amides bond (formed between PLGA and FA) are detected at around 2850 cm −1 to 2950 cm −1 , 1653 cm −1 , and 1452 cm −1 respectively [37, 38]. For the FA‐PLGA‐Alg sample, a peak at around 1642 cm −1 is stood for the stretch vibration of carbonyl groups whereas the sharp peaks at around 2980 cm −1 and 1436 cm −1 are assigned to methyl groups and the ester bonds between PLGA and Alg respectively [39]. After Dox entrapment in the fabricated nanocarrier, the aromatic peaks at around 1500 cm −1 and 1600 cm −1 confirm the aromatic absorption and presence of Dox, and the wide characteristic peak at around 3100 cm −1 to 3700 cm −1 are responsible for the hydrogen‐bonded OH stretching [40].…”

Section: Resultsmentioning

confidence: 99%

Poly lactic‐co‐glycolic acid‐alginate nanocarrier for efficient drug delivery to liver cancer cells

Hoseinzadeh

Mokhtari

Kafilzadeh

et al. 2023

IET Nanobiotechnology

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Efficient drug delivery systems (DDSs) can potentially replace with conventional modalities in cancer therapy, like liver cancer. In this study, a novel folic acid (FA)‐functionalised and alginate (Alg)‐modified poly lactic‐co‐glycolic acid (PLGA) nanocomposite was developed for delivery of doxorubicin (Dox) to HepG2 and Huh7 liver cancer cells. After synthesising the nanocarrier, several analytical devices, including FT‐IR, DLS, TGA, and TEM, were employed for its characterisation. Nano‐metric size (55 and 85 nm in diameter), close to neutral surface charge, semi‐spherical morphology, and successful synthesis were approved. Dox entrapment efficiency was determined near 1%, and sustained and pH‐sensitive drug release behaviours of nanocarrier were ascertained for DDS. Afterwards, the cell viability test was carried out to study the HepG2 and Huh7 cells suppression capability of FA‐PLGA‐Dox‐Alg. About 12% and 10% cell viabilities were observed in HepG2 and Huh7 cancer cells after 24 h treatment with 400 nM concentration of FA‐PLGA‐Dox‐Alg nanocarrier respectively. The IC50 value was observed for 100 nM after 24 h of treatment in cancer cells. These data have indicated that fabricated nanocarrier could be promising DDS against liver cancer and replace with conventional approaches in cancer treatment, like chemotherapy.

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“…In addition, various alginate derivatives including amphiphilic alginate and cell-interactive alginate have also been used in the fabrication of hydrogels for biomedical applications. Amphiphilic alginate derivatives obtained by coupling hydrophobic moieties, such as alkyl chains and hydrophobic polymers, to an alginate skeleton can self-assemble to form hydrogels in aqueous solution, which have promising prospect in drug delivery systems [78].…”

Section: Alginate and Alginate-based Hydrogelmentioning

confidence: 99%

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Zhao,

Zhou,

Zhang

et al. 2023

Pharmaceutics

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Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical applications of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing, and other biomedical fields are summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymers, novel technologies such as enzymatic and biological methods have been developed to improve their structural properties, and the development of new natural-based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels, and hydrogel microrobots have been designed to meet the advanced requirements in biomedical applications, and new strategies such as dual-cross-linking, microfluidic chip, micropatterning, and 3D/4D bioprinting have been explored to fabricate advanced hydrogel materials with designed properties for biomedical applications. Overall, natural polymeric hydrogels have attracted increasing interest in biomedical applications, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication are highly desirable and still challenging.

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Drug release behavior of poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA) prepared by direct polycondensation

Cited by 12 publications

References 20 publications

Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

Poly lactic‐co‐glycolic acid‐alginate nanocarrier for efficient drug delivery to liver cancer cells

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

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